IGF1 抗体
Quick Overview for IGF1 抗体 (ABIN6296313)
抗原
See all IGF1 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- Mouse anti-Human/Mouse/Rat/Rabbit IGF-1 Antibody [Sodium Azide Free]
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特异性
- Cytoplasmic (secreted)
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纯化方法
- Full-length recombinant human IGF1 protein was used as the immunogen for the IGF-1 antibody.
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免疫原
- Full-length recombinant human IGF1 protein was used as the immunogen for the IGF-1 antibody.
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应用备注
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Flow Cytometry: 0.5-1 μg/million cells in 0.1ml
Immunofluorescence: 1-2 μg/mL
Functional Activity: In-vitro neutralization of biological activity of IGF-1 (Order SAF formulation) -
限制
- 仅限研究用
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缓冲液
- In 1X PBS, BSA free, sodium azide free
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储存液
- Azide free
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储存条件
- 4 °C,-20 °C
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储存方法
- 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.
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- IGF1 (Insulin-Like Growth Factor 1 (IGF1))
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别名
- Insulin-like growth factor I
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背景
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Target Description: This antibody is specific to Insulin-like Growth Factor (IGF-1) and shows minimal cross-reaction with IGF-11, Proinsulin, MSF, and Insulin. IGF-1 is a polypeptide growth factor with two isoforms that are produced by alternative splicing. Isoform 1 is also known as IGF-IB while isoform 2 is known as IGF-IA. IGF-1 stimulates the proliferation of a wide range of cell types including muscle, bone and cartilage tissue. It functions as an autocrine regulator of growth. Activation of IGF system has emerged as a key factor for tumor progression and resistance to apoptosis in many cancers like those of breast, thyroid and colon.
Gene Symbol: IGF1///IBP1
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基因ID
- 3479
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UniProt
- P05019
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途径
- RTK signaling, Intracellular Steroid Hormone Receptor Signaling Pathway, Peptide Hormone Metabolism, Hormone Activity, Regulation of Intracellular Steroid Hormone Receptor Signaling, Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Stem Cell Maintenance, Glycosaminoglycan Metabolic Process, Regulation of Carbohydrate Metabolic Process, Autophagy, Smooth Muscle Cell Migration, Activated T Cell Proliferation, Positive Regulation of fat Cell Differentiation
抗原
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