L45mt antibody, MRP-L45 antibody, 2600005P05Rik antibody, AU043542 antibody, R75241 antibody, mrlp45 antibody, mitochondrial ribosomal protein L45 antibody, mitochondrial ribosomal protein L45 L homeolog antibody, Mrpl45 antibody, MRPL45 antibody, mrpl45.L antibody
背景
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75 % protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Alternative splicing results in multiple transcript variants. Pseudogenes corresponding to this gene are found on chromosomes 2p and 17q.