IBTK 抗体
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- 抗原 See all IBTK 抗体
- IBTK (Inhibitor of Bruton Agammaglobulinemia Tyrosine Kinase (IBTK))
- 适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This IBTK antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 纯化方法
- Affinity purification
- 免疫原
- Recombinant protein of human IBTK
- 亚型
- IgG
- Top Product
- Discover our top product IBTK Primary Antibody
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- 应用备注
- WB 1:500 - 1:2000
- 说明
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Expressed in DeFew, HEK293T, HeLa and in Jurkat, MC3 and NB4 lymphoid cells (at protein level), Isoform 1 is the predominant isoform expressed in all examined tissues and cell lines, Highly expressed in hemopoietic tissues (fetal liver, spleen, lymph node, thymus, peripheral blood leukocytes and bone marrow), Weakly or not expressed in other tissues
- 限制
- 仅限研究用
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- 缓冲液
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20C. Avoid freeze / thaw cycles.
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- 抗原
- IBTK (Inhibitor of Bruton Agammaglobulinemia Tyrosine Kinase (IBTK))
- 别名
- IBTK (IBTK 产品)
- 别名
- IBTK antibody, fi40c08 antibody, wu:fi40c08 antibody, DKFZp468J085 antibody, BTBD26 antibody, BTKI antibody, RP1-93K22.1 antibody, 5430411K16Rik antibody, AA409502 antibody, mKIAA1417 antibody, inhibitor of Bruton tyrosine kinase antibody, inhibitor of Bruton agammaglobulinemia tyrosine kinase antibody, inhibitor of Bruton tyrosine kinase L homeolog antibody, IBTK antibody, ibtk antibody, Ibtk antibody, ibtk.L antibody
- 背景
- Bruton tyrosine kinase (BTK) is a protein tyrosine kinase that is expressed in B cells, macrophages, and neutrophils. The protein encoded by this gene binds to BTK and downregulates BTK's kinase activity. In addition, the encoded protein disrupts BTK-mediated calcium mobilization and negatively regulates the activation of nuclear factor-kappa-B-driven transcription. This gene has a pseudogene on chromosome 18. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
- 分子量
- 150.528 kDa
- 基因ID
- 25998
- UniProt
- Q9P2D0
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