Caspase-8 p18 抗体 (Cleaved-Ser217, Internal Region)
适用: 人
WB, ELISA, IF
宿主: 兔
Polyclonal
unconjugated
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- 抗原 See all Caspase-8 p18 products
- Caspase-8 p18 (Caspase 8 Subunit P18)
- 抗原表位
- AA 170-250, Cleaved-Ser217, Internal Region
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This Caspase-8 p18 antibody is un-conjugated
- 应用范围
- Western Blotting (WB), ELISA, Immunofluorescence (IF)
- 原理
- Caspase-8 is a protein encoded by the CASP8 gene which is approximately 55,3 kDa. Caspase-8 is localised to the cytoplasm and is involved in the TNFR1 pathway, dimerization of procaspase-8 , activated TLR4 signalling, apoptosis signalling and toll-like receptor signalling pathways. This protein falls under the cysteine-aspartic acid protease family. It pays a role in the programmed cell death induced by Fas and various apoptotic stimuli. Caspase-8 isoform 1, 5 and 7 are expressed in a wide variety of tissues. Mutations in the CASP8 gene may result in a caspase-8 deficiency. STJ97641 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.This polyclonal antibody detects endogenous levels of fragment of activated caspase-8 p18 protein resulting from cleavage adjacent to S217.
- 特异性
- Cleaved-Caspase-8 p18 (S217) Polyclonal Antibody detects endogenous levels of Cleaved-Caspase-8 p18 (S217) protein.
- 产品特性
- Rabbit polyclonal to Cleaved-Caspase-8 p18 (S217).
- 纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- 免疫原
- Synthesized peptide derived from human Cleaved-Caspase-8 p18 (S217)
- 亚型
- IgG
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anti-Caspase 8 Subunit P18 (cleaved), (Ser217) antibody
适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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WB 1:500-1:2000
ELISA 1:10000 - 说明
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Isoform 1, isoform 5 and isoform 7 are expressed in a wide variety of tissues. Highest expression in peripheral blood leukocytes, spleen, thymus and liver. Barely detectable in brain, testis and skeletal muscle.
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20°C, and avoid repeat freeze-thaw cycles.
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- 抗原
- Caspase-8 p18 (Caspase 8 Subunit P18)
- 别名
- Caspase-8 p18 (Caspase-8 p18 产品)
- 别名
- ALPS2B antibody, CAP4 antibody, Casp-8 antibody, FLICE antibody, MACH antibody, MCH5 antibody, CASP-8 antibody, Mch5 antibody, caspase 8 antibody, CASP8 antibody, Casp8 antibody
- 基因ID
- 841
- UniProt
- Q14790
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