ZC3HAV1 抗体 (Internal Region)
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- 抗原 See all ZC3HAV1 抗体
- ZC3HAV1 (Zinc Finger CCCH-Type, Antiviral 1 (ZC3HAV1))
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抗原表位
- Internal Region
- 适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This ZC3HAV1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC)
- 特异性
- ZC3HAV1 Antibody detects endogenous levels of total ZC3HAV1.
- 纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- 免疫原
- A synthesized peptide derived from human ZC3HAV1, corresponding to a region within the internal amino acids.
- 亚型
- IgG
- Top Product
- Discover our top product ZC3HAV1 Primary Antibody
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anti-Zinc Finger CCCH-Type, Antiviral 1 (ZC3HAV1) antibody
ZC3HAV1 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Zinc Finger CCCH-Type, Antiviral 1 (ZC3HAV1) (AA 150-400) antibodyZC3HAV1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Zinc Finger CCCH-Type, Antiviral 1 (ZC3HAV1) (AA 604-632), (C-Term) antibodyZC3HAV1 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB24221 unconjugated
anti-Zinc Finger CCCH-Type, Antiviral 1 (ZC3HAV1) (C-Term) antibodyZC3HAV1 适用: 人 WB, IF, EIA 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB 1:500-1:2000, IHC 1:50-1:200
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
- 有效期
- 12 months
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- 抗原
- ZC3HAV1 (Zinc Finger CCCH-Type, Antiviral 1 (ZC3HAV1))
- 别名
- ZC3HAV1 (ZC3HAV1 产品)
- 别名
- 1200014N16Rik antibody, 2900058M19Rik antibody, 9130009D18Rik antibody, 9830115L13Rik antibody, ARTD13 antibody, D6Bwg1452e antibody, ZAP antibody, Zap antibody, FLB6421 antibody, PARP13 antibody, ZC3H2 antibody, ZC3HDC2 antibody, zinc finger CCCH type, antiviral 1 antibody, zinc finger CCCH-type containing, antiviral 1 antibody, Zc3hav1 antibody, ZC3HAV1 antibody
- 背景
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Description: Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element (ZRE) present in the target viral mRNA, recruits cellular poly(A)-specific ribonuclease PARN to remove the poly(A) tail, and the 3'-5' exoribonuclease complex exosome to degrade the RNA body from the 3'-end. It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72 (DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the 5'-end. Its target viruses belong to families which include retroviridae: human immunodeficiency virus type 1 (HIV-1), moloney and murine leukemia virus (MoMLV) and xenotropic MuLV-related virus (XMRV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), togaviridae: sindbis virus (SINV) and Ross river virus (RRV). Specifically targets the multiply spliced but not unspliced or singly spliced HIV-1 mRNAs for degradation. Isoform 1 is a more potent viral inhibitor than isoform 2. Isoform 2 acts as a positive regulator of DDX58/RIG-I signaling resulting in activation of the downstream effector IRF3 leading to the expression of type I IFNs and IFN stimulated genes (ISGs).
Gene: ZC3HAV1
- 分子量
- 100 kDa
- 基因ID
- 56829
- UniProt
- Q7Z2W4
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