TIMELESS 抗体 (C-Term)
Quick Overview for TIMELESS 抗体 (C-Term) (ABIN6265574)
抗原
See all TIMELESS 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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特异性
- TIMELESS Antibody detects endogenous levels of total TIMELESS.
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预测反应
- Pig
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纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
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免疫原
- A synthesized peptide derived from human TIMELESS, corresponding to a region within C-terminal amino acids.
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亚型
- IgG
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anti-Timeless Homolog (TIMELESS) (AA 1-1208) antibody
TIMELESS 适用: 人 WB, IP, IF 宿主: 兔 Polyclonal unconjugated
anti-Timeless Homolog (TIMELESS) (N-Term) antibodyTIMELESS 适用: 人 WB, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-Timeless Homolog (TIMELESS) (AA 1004-1131) antibodyTIMELESS 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Timeless Homolog (TIMELESS) (AA 290-339) antibodyTIMELESS 适用: 人, 小鼠, 大鼠, 犬, 马, 豚鼠, Pig, 兔 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Timeless Homolog (TIMELESS) (AA 1-1208) antibodyTIMELESS 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Timeless Homolog (TIMELESS) (N-Term) antibodyTIMELESS 适用: 人, 小鼠, 大鼠, 犬, Cow WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Timeless Homolog (TIMELESS) (N-Term) antibodyTIMELESS 适用: 人, 小鼠, 大鼠, 犬, Cow, 马, 豚鼠, 绵羊, Pig, 兔 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Timeless Homolog (TIMELESS) (AA 1109-1207) antibodyTIMELESS 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Timeless Homolog (TIMELESS) (N-Term) antibodyTIMELESS 适用: 人, 犬, Cow, 马, 绵羊, Pig, 兔, Bat, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Timeless Homolog (TIMELESS) (C-Term) antibodyTIMELESS 适用: 人, 大鼠, Cow, 马, 豚鼠, 绵羊 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
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有效期
- 12 months
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- TIMELESS (Timeless Homolog (TIMELESS))
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别名
- TIMELESS
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背景
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Description: Plays an important role in the control of DNA replication, maintenance of replication fork stability, maintenance of genome stability throughout normal DNA replication and in the regulation of the circadian clock. Involved in the determination of period length and in the DNA damage-dependent phase advancing of the circadian clock. Negatively regulates CLOCK|NPAS2-ARTNL/BMAL1|ARTNL2/BMAL2-induced transactivation of PER1 possibly via translocation of PER1 into the nucleus. Forms a complex with TIPIN and this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress. Timeless promotes TIPIN nuclear localization. Involved in cell survival after DNA damage or replication stress. May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light. May also play an important role in epithelial cell morphogenesis and formation of branching tubules.
Gene: TIMELESS
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分子量
- 139 kDa
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基因ID
- 8914
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UniProt
- Q9UNS1
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途径
- Protein targeting to Nucleus, Photoperiodism
抗原
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