TARDBP 抗体 (C-Term)
Quick Overview for TARDBP 抗体 (C-Term) (ABIN6265515)
抗原
See all TARDBP 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- C-Term
-
特异性
- TDP43 Antibody detects endogenous levels of total TDP43.
-
预测反应
- Zebrafish,Dog,Chicken
-
纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
-
免疫原
- A synthesized peptide derived from human TDP43, corresponding to a region within C-terminal amino acids.
-
亚型
- IgG
-
-
-
-
应用备注
- WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
浓度
- 1 mg/mL
-
缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C
-
储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
-
有效期
- 12 months
-
-
- TARDBP (TAR DNA Binding Protein (TARDBP))
-
别名
- TARDBP
-
背景
-
Description: DNA and RNA-binding protein which regulates transcription and splicing. Involved in the regulation of CFTR splicing. It promotes CFTR exon 9 skipping by binding to the UG repeated motifs in the polymorphic region near the 3'-splice site of this exon. The resulting aberrant splicing is associated with pathological features typical of cystic fibrosis. May also be involved in microRNA biogenesis, apoptosis and cell division. Can repress HIV-1 transcription by binding to the HIV-1 long terminal repeat. Stabilizes the low molecular weight neurofilament (NFL) mRNA through a direct interaction with the 3' UTR.
Gene: TARDBP
-
分子量
- 43 kDa
-
基因ID
- 23435
-
UniProt
- Q13148
-
途径
- Positive Regulation of Peptide Hormone Secretion
抗原
-