SHARPIN 抗体 (Internal Region)
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- 抗原 See all SHARPIN 抗体
- SHARPIN (SHANK-Associated RH Domain Interacting Protein (SHARPIN))
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抗原表位
- Internal Region
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适用
- 人, 大鼠, 小鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This SHARPIN antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC)
- 特异性
- SHARPIN Antibody detects endogenous levels of total SHARPIN.
- 预测反应
- Pig,Bovine,Horse,Sheep
- 纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- 免疫原
- A synthesized peptide derived from human SHARPIN, corresponding to a region within the internal amino acids.
- 亚型
- IgG
- Top Product
- Discover our top product SHARPIN Primary Antibody
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anti-SHANK-Associated RH Domain Interacting Protein (SHARPIN) (AA 82-171) antibody
SHARPIN 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-SHANK-Associated RH Domain Interacting Protein (SHARPIN) (AA 1-326) antibodySHARPIN 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-SHANK-Associated RH Domain Interacting Protein (SHARPIN) (AA 51-148) antibodySHARPIN 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-SHANK-Associated RH Domain Interacting Protein (SHARPIN) (AA 301-350) antibodySHARPIN 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-SHANK-Associated RH Domain Interacting Protein (SHARPIN) (AA 1-170) antibodySHARPIN 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-SHANK-Associated RH Domain Interacting Protein (SHARPIN) (C-Term) antibodySHARPIN 适用: 人, 大鼠, Cow WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB 1:500-1:2000, IHC 1:50-1:200
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
- 有效期
- 12 months
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- 抗原
- SHARPIN (SHANK-Associated RH Domain Interacting Protein (SHARPIN))
- 别名
- SHARPIN (SHARPIN 产品)
- 别名
- 0610041B22Rik antibody, AW121341 antibody, RBCKL1 antibody, SIPL1 antibody, cpdm antibody, Conneck1 antibody, SHANK-associated RH domain interacting protein antibody, SHANK associated RH domain interactor antibody, SHANK-associated RH domain interactor antibody, Sharpin antibody, SHARPIN antibody
- 背景
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Description: Component of the LUBAC complex which conjugates linear polyubiquitin chains in a head-to-tail manner to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Together with FAM105B/otulin, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis.
Gene: SHARPIN
- 分子量
- 40 kDa
- 基因ID
- 81858
- UniProt
- Q9H0F6
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