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- 抗原 See all Sestrin 2 (SESN2) 抗体
- Sestrin 2 (SESN2)
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适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This Sestrin 2 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC)
- 特异性
- Sestrin 2 antibody detects endogenous levels of Sestrin 2.
- 交叉反应
- 人, 小鼠, 大鼠
- 纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- 免疫原
- A synthesized peptide derived from human Sestrin 2.
- 亚型
- IgG
- Top Product
- Discover our top product SESN2 Primary Antibody
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anti-Sestrin 2 (SESN2) (AA 1-480) antibody
SESN2 适用: 人 WB, ELISA, IP, IF, IHC (p) 宿主: 小鼠 Monoclonal 3B8 unconjugated
anti-Sestrin 2 (SESN2) (AA 1-480) antibodySESN2 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1A12 unconjugated
anti-Sestrin 2 (SESN2) (AA 41-480) antibodySESN2 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Sestrin 2 (SESN2) (AA 42-61) antibodySESN2 适用: 人 ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Sestrin 2 (SESN2) (AA 1-480) antibodySESN2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Sestrin 2 (SESN2) (AA 268-317) antibodySESN2 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Sestrin 2 (SESN2) (N-Term) antibodySESN2 适用: 人, Cow, 犬, 豚鼠, 马, Pig, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Sestrin 2 (SESN2) (AA 211-480) antibodySESN2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Sestrin 2 (SESN2) (AA 283-311) antibodySESN2 适用: 人 WB, FACS 宿主: 兔 Polyclonal RB18603 unconjugated
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- 应用备注
- WB 1:500-1:2000, IHC 1:50-1:200
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20 °C.Stable for 12 months from date of receipt
- 有效期
- 12 months
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- 抗原
- Sestrin 2 (SESN2)
- 别名
- Sestrin 2 (SESN2 产品)
- 别名
- HI95 antibody, SES2 antibody, SEST2 antibody, Ses2 antibody, MGC81239 antibody, SESN2 antibody, sestrin-2 antibody, hi95 antibody, ses2 antibody, sest2 antibody, Sestrin-2 antibody, RGD1566319 antibody, sestrin 2 antibody, sestrin 2 L homeolog antibody, SESN2 antibody, Sesn2 antibody, sesn2.L antibody, sesn2 antibody
- 背景
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Description: Functions as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway through the GATOR complex. In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents TORC1 signaling (PubMed:18692468, PubMed:25263562, PubMed:25457612, PubMed:26449471, PubMed:26612684, PubMed:26586190). Binding of leucine to SESN2 disrupts its interaction with GATOR2 thereby activating the TORC1 signaling pathway (PubMed:26449471, PubMed:26586190). This stress-inducible metabolic regulator also plays a role in protection against oxidative and genotoxic stresses. May negatively regulate protein translation in response to endoplasmic reticulum stress, via TORC1 (PubMed:24947615). May positively regulate the transcription by NFE2L2 of genes involved in the response to oxidative stress by facilitating the SQSTM1-mediated autophagic degradation of KEAP1 (PubMed:23274085). May also mediate TP53 inhibition of TORC1 signaling upon genotoxic stress (PubMed:18692468). Has an alkylhydroperoxide reductase activity born by the N-terminal domain of the protein (PubMed:26612684). Was originally reported to contribute to oxidative stress resistance by reducing PRDX1 (PubMed:15105503). However, this could not be confirmed (PubMed:19113821).
Gene: SESN2
- 分子量
- 54-60 kDa
- 基因ID
- 83667
- UniProt
- P58004
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