PTPRN2 抗体 (Internal Region)
-
- 抗原 See all PTPRN2 抗体
- PTPRN2 (Protein tyrosine Phosphatase, Receptor Type, N Polypeptide 2 (PTPRN2))
-
抗原表位
- Internal Region
- 适用
- 人, 小鼠, 大鼠
-
宿主
- 兔
-
克隆类型
- 多克隆
-
标记
- This PTPRN2 antibody is un-conjugated
-
应用范围
- Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)
- 特异性
- PTP IA-2beta Antibody detects endogenous levels of total PTP IA-2beta.
- 预测反应
- Pig,Dog
- 纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- 免疫原
- A synthesized peptide derived from human PTP IA-2beta, corresponding to a region within the internal amino acids.
- 亚型
- IgG
- Top Product
- Discover our top product PTPRN2 Primary Antibody
-
anti-Protein tyrosine Phosphatase, Receptor Type, N Polypeptide 2 (PTPRN2) (AA 22-242) antibody
PTPRN2 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Protein tyrosine Phosphatase, Receptor Type, N Polypeptide 2 (PTPRN2) antibodyPTPRN2 适用: 人, 小鼠, 大鼠 IHC 宿主: 兔 Polyclonal unconjugated
anti-Protein tyrosine Phosphatase, Receptor Type, N Polypeptide 2 (PTPRN2) (AA 108-212) antibodyPTPRN2 适用: 人 WB, ELISA, RNAi 宿主: 小鼠 Monoclonal 7F8 unconjugated
anti-Protein tyrosine Phosphatase, Receptor Type, N Polypeptide 2 (PTPRN2) (AA 1-986) antibodyPTPRN2 适用: 人 WB, IHC (p) 宿主: 小鼠 Polyclonal unconjugated
anti-Protein tyrosine Phosphatase, Receptor Type, N Polypeptide 2 (PTPRN2) (AA 1-986) antibodyPTPRN2 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Protein tyrosine Phosphatase, Receptor Type, N Polypeptide 2 (PTPRN2) (AA 108-212) antibodyPTPRN2 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3E2 unconjugated
anti-Protein tyrosine Phosphatase, Receptor Type, N Polypeptide 2 (PTPRN2) antibodyPTPRN2 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Protein tyrosine Phosphatase, Receptor Type, N Polypeptide 2 (PTPRN2) (N-Term) antibodyPTPRN2 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Protein tyrosine Phosphatase, Receptor Type, N Polypeptide 2 (PTPRN2) (AA 839-1015) antibodyPTPRN2 适用: 人 WB, IHC, ICC 宿主: 兔 Polyclonal unconjugated
anti-Protein tyrosine Phosphatase, Receptor Type, N Polypeptide 2 (PTPRN2) (AA 782-1001) antibodyPTPRN2 适用: 小鼠 WB, IHC, ICC 宿主: 兔 Polyclonal unconjugated
-
- 应用备注
- WB 1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
- 限制
- 仅限研究用
-
- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
- 有效期
- 12 months
-
- 抗原
- PTPRN2 (Protein tyrosine Phosphatase, Receptor Type, N Polypeptide 2 (PTPRN2))
- 别名
- PTPRN2 (PTPRN2 产品)
- 别名
- IA-2beta antibody, IAR antibody, ICAAR antibody, PTPRP antibody, R-PTP-N2 antibody, 4930425H11Rik antibody, IA2beta antibody, PTP-NP antibody, Phol antibody, mKIAA0387 antibody, phogrin antibody, protein tyrosine phosphatase, receptor type N2 antibody, protein tyrosine phosphatase, receptor type, N polypeptide 2 antibody, PTPRN2 antibody, Ptprn2 antibody
- 背景
-
Description: Plays a role in vesicle-mediated secretory processes. Required for normal accumulation of secretory vesicles in hippocampus, pituitary and pancreatic islets. Required for the accumulation of normal levels of insulin-containing vesicles and preventing their degradation. Plays a role in insulin secretion in response to glucose stimuli. Required for normal accumulation of the neurotransmitters norepinephrine, dopamine and serotonin in the brain. In females, but not in males, required for normal accumulation and secretion of pituitary hormones, such as luteinizing hormone (LH) and follicle-stimulating hormone (FSH) (By similarity). Required to maintain normal levels of renin expression and renin release (By similarity). May regulate catalytic active protein-tyrosine phosphatases such as PTPRA through dimerization (By similarity). Has phosphatidylinositol phosphatase activity, the PIPase activity is involved in its ability to regulate insulin secretion. Can dephosphorylate phosphatidylinositol 4,5-biphosphate (PI(4,5)P2), phosphatidylinositol 5-phosphate and phosphatidylinositol 3-phosphate (By similarity). Regulates PI(4,5)P2 level in the plasma membrane and localization of cofilin at the plasma membrane and thus is indirectly involved in regulation of actin dynamics related to cell migration and metastasis, upon hydrolyzation of PI(4,5)P2 cofilin is released from the plasma membrane and acts in the cytoplasm in severing F-actin filaments (PubMed:26620550).
Gene: PTPRN2
- 分子量
- 111kDa
- 基因ID
- 5799
- UniProt
- Q92932
-
