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- 抗原 See all PDCD6 抗体
- PDCD6 (Programmed Cell Death 6 (PDCD6))
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抗原表位
- Internal Region
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This PDCD6 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA
- 特异性
- PDCD6 Antibody detects endogenous levels of total PDCD6.
- 预测反应
- Pig,Zebrafish,Bovine,Horse,Rabbit,Dog,Chicken,Xenopus
- 纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- 免疫原
- A synthesized peptide derived from human PDCD6, corresponding to a region within the internal amino acids.
- 亚型
- IgG
- Top Product
- Discover our top product PDCD6 Primary Antibody
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anti-Programmed Cell Death 6 (PDCD6) (AA 32-191) antibody
PDCD6 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Programmed Cell Death 6 (PDCD6) (AA 92-191) antibodyPDCD6 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 2B4 unconjugated
anti-Programmed Cell Death 6 (PDCD6) (AA 1-191) antibodyPDCD6 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Programmed Cell Death 6 (PDCD6) antibodyPDCD6 适用: 人, 小鼠, 大鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Programmed Cell Death 6 (PDCD6) antibodyPDCD6 适用: 人 WB, IF, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Programmed Cell Death 6 (PDCD6) antibodyPDCD6 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Programmed Cell Death 6 (PDCD6) (AA 103-137) antibodyPDCD6 适用: 小鼠 WB 宿主: 兔 Polyclonal RB49787 unconjugated
anti-Programmed Cell Death 6 (PDCD6) (AA 19-47), (N-Term) antibodyPDCD6 适用: 人 WB 宿主: 兔 Polyclonal RB41816 unconjugated
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- 应用备注
- WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
- 有效期
- 12 months
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- 抗原
- PDCD6 (Programmed Cell Death 6 (PDCD6))
- 别名
- PDCD6 (PDCD6 产品)
- 别名
- pdcd6 antibody, MGC52821 antibody, MGC132114 antibody, zgc:63952 antibody, PDCD6 antibody, ALG-2 antibody, PEF1B antibody, AV299538 antibody, Alg2 antibody, MA-3 antibody, PS2 antibody, alg-2 antibody, programmed cell death 6 L homeolog antibody, programmed cell death 6 antibody, pdcd6.L antibody, pdcd6 antibody, PDCD6 antibody, Pdcd6 antibody
- 背景
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Description: Calcium sensor that plays a key role in processes such as endoplasmic reticulum (ER)-Golgi vesicular transport, endosomal biogenesis or membrane repair. Acts as an adapter that bridges unrelated proteins or stabilizes weak protein-protein complexes in response to calcium: calcium-binding triggers exposure of apolar surface, promoting interaction with different sets of proteins thanks to 3 different hydrophobic pockets, leading to translocation to membranes (PubMed:20691033, PubMed:25667979). Involved in ER-Golgi transport by promoting the association between PDCD6IP and TSG101, thereby bridging together the ESCRT-III and ESCRT-I complexes (PubMed:19520058). Together with PEF1, acts as calcium-dependent adapter for the BCR(KLHL12) complex, a complex involved in ER-Golgi transport by regulating the size of COPII coats (PubMed:27716508). In response to cytosolic calcium increase, the heterodimer formed with PEF1 interacts with, and bridges together the BCR(KLHL12) complex and SEC31 (SEC31A or SEC31B), promoting monoubiquitination of SEC31 and subsequent collagen export, which is required for neural crest specification (PubMed:27716508). Involved in the regulation of the distribution and function of MCOLN1 in the endosomal pathway (PubMed:19864416). Promotes localization and polymerization of TFG at endoplasmic reticulum exit site (PubMed:27813252). Required for T-cell receptor-, Fas-, and glucocorticoid-induced apoptosis (By similarity). May mediate Ca2+-regulated signals along the death pathway: interaction with DAPK1 can accelerate apoptotic cell death by increasing caspase-3 activity (PubMed:16132846). Its role in apoptosis may however be indirect, as suggested by knockout experiments (By similarity). May inhibit KDR/VEGFR2-dependent angiogenesis, the function involves inhibition of VEGF-induced phosphorylation of the Akt signaling pathway (PubMed:21893193). In case of infection by HIV-1 virus, indirectly inhibits HIV-1 production by affecting viral Gag expression and distribution (PubMed:27784779).
Gene: PDCD6
- 分子量
- 21 kDa
- 基因ID
- 10016
- UniProt
- O75340
- 途径
- Positive Regulation of Endopeptidase Activity
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