NUDT21 抗体 (Internal Region)
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- 抗原 See all NUDT21 抗体
- NUDT21 (Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 21 (NUDT21))
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抗原表位
- Internal Region
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适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This NUDT21 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC)
- 特异性
- NUDT21 Antibody detects endogenous levels of total NUDT21.
- 预测反应
- Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Chicken,Xenopus
- 纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- 免疫原
- A synthesized peptide derived from human NUDT21, corresponding to a region within the internal amino acids.
- 亚型
- IgG
- Top Product
- Discover our top product NUDT21 Primary Antibody
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anti-Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 21 (NUDT21) (AA 1-227) antibody
NUDT21 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 3F8 unconjugated
anti-Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 21 (NUDT21) (AA 2-227) antibodyNUDT21 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 21 (NUDT21) (AA 1-227) antibodyNUDT21 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 21 (NUDT21) (N-Term) antibodyNUDT21 适用: 人, 小鼠, 大鼠, 斑马鱼, 犬, 兔, Cow, 豚鼠, 马, Bat, 小鸡, 猴, 非洲爪蟾 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 21 (NUDT21) (N-Term) antibodyNUDT21 适用: 人, 小鼠, 大鼠, 斑马鱼, 犬, 兔, Cow, 豚鼠, 马 WB, IHC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB 1:500-1:2000, IHC 1:50-1:200
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
- 有效期
- 12 months
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- 抗原
- NUDT21 (Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 21 (NUDT21))
- 别名
- NUDT21 (NUDT21 产品)
- 别名
- CFIM25 antibody, CPSF5 antibody, 25kDa antibody, 3110048P04Rik antibody, 5730530J16Rik antibody, AU014860 antibody, AW549947 antibody, Cpsf5 antibody, zgc:63966 antibody, cpsf5 antibody, An16g01870 antibody, AO090003001316 antibody, Afu5g02030 antibody, T9L24.30 antibody, T9L24_30 antibody, atnudt21 antibody, nudix hydrolase homolog 21 antibody, nudix hydrolase 21 antibody, nudix (nucleoside diphosphate linked moiety X)-type motif 21 antibody, nudix hydrolase 21 L homeolog antibody, cleavage and polyadenylation specificity factor subunit 5 antibody, cleavage and polyadenylation specific factor 5 antibody, autocrine motility factor receptor antibody, nudix hydrolase homolog 21 antibody, NUDT21 antibody, Nudt21 antibody, nudt21 antibody, nudt21.L antibody, ANI_1_1518144 antibody, AOR_1_2312154 antibody, PTRG_11035 antibody, PAAG_04662 antibody, MCYG_02022 antibody, VDBG_06706 antibody, MGYG_04057 antibody, cpsf5 antibody, PGTG_05353 antibody, Tsp_03672 antibody, LOC732888 antibody, AFUA_5G02030 antibody, NFIA_040090 antibody, ACLA_003240 antibody, CC1G_07993 antibody, PMAA_039710 antibody, AFLA_025180 antibody, TSTA_079060 antibody, BDBG_01565 antibody, TERG_04393 antibody
- 背景
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Description: Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs (PubMed:9659921, PubMed:8626397, PubMed:14690600, PubMed:15937220, PubMed:17024186, PubMed:17098938, PubMed:29276085). CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals) (PubMed:9659921, PubMed:8626397, PubMed:14690600, PubMed:17024186). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation (PubMed:17098938, PubMed:23187700, PubMed:29276085). The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs (PubMed:17098938, PubMed:20695905, PubMed:29276085). NUDT21/CPSF5 activates indirectly the mRNA 3'-processing machinery by recruiting CPSF6 and/or CPSF7 (PubMed:29276085). Binds to 5'-UGUA-3' elements localized upstream of pA signals that act as enhancers of pre-mRNA 3'-end processing (PubMed:8626397, PubMed:14690600, PubMed:15169763, PubMed:17024186, PubMed:22813749, PubMed:20479262). The homodimer mediates simultaneous sequence-specific recognition of two 5'-UGUA-3' elements within the pre-mRNA (PubMed:20479262, PubMed:21295486). Plays a role in somatic cell fate transitions and pluripotency by regulating widespread changes in gene expression through an APA-dependent function (By similarity). Binds to chromatin (By similarity). Binds to, but does not hydrolyze mono- and di-adenosine nucleotides (PubMed:18445629).
Gene: NUDT21
- 分子量
- 26 kDa
- 基因ID
- 11051
- UniProt
- O43809
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