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LSD1 抗体 (Internal Region)

Name: LSD1 抗体 (Internal Region)
SKU: ABIN6276559
Availability: OutOfStock

KDM1A 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated

Western blot analysis of extracts of PC12 lysate using KDM1A antibody. (LSD1 抗体 (Internal Region))

ABIN6276559 at 1/100 staining Mouse colon tissue by IHC-P. (LSD1 抗体 (Internal Region))

IHC

2 images

产品编号 ABIN6276559

发货至: 中国

Datasheet as PDF

抗原 See all LSD1 (KDM1A) 抗体

LSD1 (KDM1A) (Lysine (K)-Specific Demethylase 1A (KDM1A))
抗原表位
15

7

7

6

3

3

3

3

2

2

2

2

1

1

1

1

1

1

1

1

1
Internal Region
适用
75

37

29

6

3

2

1

1

1

1

1

1

1
人, 小鼠, 大鼠
宿主
60

14

1

1
兔
Compatible Secondaries
克隆类型
62

15
多克隆
标记
57

3

3

3

1

1

1

1

1

1

1

1

1

1

1
This LSD1 antibody is un-conjugated
应用范围
69

34

26

20

17

13

13

11

5

4

4

4

3

2

2

1

1
Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

特异性

KDM1A Antibody detects endogenous levels of total KDM1A.

预测反应

Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

纯化方法

The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

免疫原

A synthesized peptide derived from human KDM1A, corresponding to a region within the internal amino acids.

亚型

IgG

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anti-Lysine (K)-Specific Demethylase 1A (KDM1A) (AA 130-380) antibody
KO Validated KDM1A 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Lysine (K)-Specific Demethylase 1A (KDM1A) (AA 709-876) antibody
KDM1A 适用: 人, 小鼠, 猴 WB, ELISA, IHC, FACS 宿主: 小鼠 Monoclonal 1H2F8 unconjugated

anti-Lysine (K)-Specific Demethylase 1A (KDM1A) (AA 55-263) antibody
KDM1A 适用: 人 WB, ELISA, IHC, FACS, ICC 宿主: 小鼠 Monoclonal 3F9D2 unconjugated

anti-Lysine (K)-Specific Demethylase 1A (KDM1A) (AA 55-263) antibody
KDM1A 适用: 人, 猴 WB, ELISA, IHC, FACS, ICC 宿主: 小鼠 Monoclonal 3F9A3 unconjugated

anti-Lysine (K)-Specific Demethylase 1A (KDM1A) (AA 753-851) antibody
KDM1A 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 2E7 unconjugated

anti-Lysine (K)-Specific Demethylase 1A (KDM1A) (AA 108-142) antibody
KDM1A 适用: 人, 小鼠 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Lysine (K)-Specific Demethylase 1A (KDM1A) (AA 819-852) antibody
KDM1A 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Lysine (K)-Specific Demethylase 1A (KDM1A) (AA 819-852), (C-Term) antibody
KDM1A 适用: 人 WB, IF, IHC (p) 宿主: 兔 Polyclonal RB7583 unconjugated

anti-Lysine (K)-Specific Demethylase 1A (KDM1A) (AA 100-150) antibody
KDM1A 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated

应用备注

WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000

限制

仅限研究用
状态

Liquid

浓度

1 mg/mL

缓冲液

Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

-20 °C

储存方法

Store at -20 °C. Stable for 12 months from date of receipt.

有效期

12 months
抗原

LSD1 (KDM1A) (Lysine (K)-Specific Demethylase 1A (KDM1A))

别名

KDM1A (KDM1A 产品)

别名

AOF2 antibody, BHC110 antibody, KDM1 antibody, LSD1 antibody, 1810043O07Rik antibody, AA408884 antibody, Aof2 antibody, D4Ertd478e antibody, Kdm1 antibody, Lsd1 antibody, mKIAA0601 antibody, DKFZp459N2450 antibody, RGD1562975 antibody, aof2 antibody, kdm1 antibody, wu:fb82e06 antibody, wu:fc51a02 antibody, wu:fj36a05 antibody, wu:fj66b06 antibody, KDM1A antibody, lsd1 antibody, xLSD1 antibody, AtLSD1 antibody, F9F13.30 antibody, F9F13_30 antibody, LESION SIMULATING DISEASE antibody, LESION SIMULATING DISEASE 1 antibody, lysine demethylase 1A antibody, lysine (K)-specific demethylase 1A antibody, lysine (K)-specific demethylase 1a antibody, LSD1 zinc finger family protein antibody, KDM1A antibody, Kdm1a antibody, kdm1a antibody, LSD1 antibody

背景

Description: Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me. May play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity. Also acts as a coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and mediating demethylation of H3K9me, a specific tag for epigenetic transcriptional repression. The presence of PRKCB in ANDR-containing complexes, which mediates phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag that prevents demethylation H3K4me, prevents H3K4me demethylase activity of KDM1A. Demethylates di-methylated 'Lys-370' of p53/TP53 which prevents interaction of p53/TP53 with TP53BP1 and represses p53/TP53-mediated transcriptional activation. Demethylates and stabilizes the DNA methylase DNMT1. Required for gastrulation during embryogenesis. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Effector of SNAI1-mediated transcription repression of E-cadherin/CDH1, CDN7 and KRT8. Required for the maintenance of the silenced state of the SNAI1 target genes E-cadherin/CDH1 and CDN7.
Gene: KDM1A

分子量

95kDa

基因ID

23028

UniProt

O60341

途径

Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Negative Regulation of intrinsic apoptotic Signaling, Warburg Effect