KCNC2 抗体 (C-Term)
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- 抗原 See all KCNC2 抗体
- KCNC2 (Potassium Voltage-Gated Channel, Shaw-Related Subfamily, Member 2 (KCNC2))
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抗原表位
- C-Term
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适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This KCNC2 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
- 特异性
- KCNC2 Antibody detects endogenous levels of total KCNC2.
- 预测反应
- Sheep,Rabbit
- 纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- 免疫原
- A synthesized peptide derived from human KCNC2, corresponding to a region within C-terminal amino acids.
- 亚型
- IgG
- Top Product
- Discover our top product KCNC2 Primary Antibody
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anti-Potassium Voltage-Gated Channel, Shaw-Related Subfamily, Member 2 (KCNC2) antibody
KCNC2 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Potassium Voltage-Gated Channel, Shaw-Related Subfamily, Member 2 (KCNC2) antibodyKCNC2 适用: 人, 小鼠, 大鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Potassium Voltage-Gated Channel, Shaw-Related Subfamily, Member 2 (KCNC2) (C-Term) antibodyKCNC2 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Potassium Voltage-Gated Channel, Shaw-Related Subfamily, Member 2 (KCNC2) (C-Term) antibodyKCNC2 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Potassium Voltage-Gated Channel, Shaw-Related Subfamily, Member 2 (KCNC2) (AA 589-638) antibodyKCNC2 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Potassium Voltage-Gated Channel, Shaw-Related Subfamily, Member 2 (KCNC2) (C-Term) antibodyKCNC2 适用: 人, 小鼠, 大鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB: 1:500-1:3000, IHC: 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
- 有效期
- 12 months
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- 抗原
- KCNC2 (Potassium Voltage-Gated Channel, Shaw-Related Subfamily, Member 2 (KCNC2))
- 别名
- KCNC2 (KCNC2 产品)
- 别名
- KV3.2 antibody, KShIIIA antibody, Kv3.2 antibody, AW047325 antibody, B230117I07 antibody, KCNC2 antibody, zgc:162956 antibody, potassium voltage-gated channel subfamily C member 2 antibody, potassium voltage gated channel, Shaw-related subfamily, member 2 antibody, potassium voltage-gated channel, Shaw-related subfamily, member 2 antibody, potassium channel, voltage gated Shaw related subfamily C, member 2 antibody, KCNC2 antibody, Kcnc2 antibody, kcnc2 antibody
- 背景
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Description: Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain. Contributes to the regulation of the fast action potential repolarization and in sustained high-frequency firing in neurons of the central nervous system. Homotetramer channels mediate delayed-rectifier voltage-dependent potassium currents that activate rapidly at high-threshold voltages and inactivate slowly. Forms tetrameric channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:15709110). Can form functional homotetrameric and heterotetrameric channels that contain variable proportions of KCNC1, and possibly other family members as well, channel properties depend on the type of alpha subunits that are part of the channel. Channel properties may be modulated either by the association with ancillary subunits, such as KCNE1, KCNE2 or KCNE3 or indirectly by nitric oxide (NO) through a cGMP- and PKG-mediated signaling cascade, slowing channel activation and deactivation of delayed rectifier potassium channels (By similarity). Contributes to fire sustained trains of very brief action potentials at high frequency in retinal ganglion cells, thalamocortical and suprachiasmatic nucleus (SCN) neurons and in hippocampal and neocortical interneurons (PubMed:15709110). Sustained maximal action potential firing frequency in inhibitory hippocampal interneurons is negatively modulated by histamine H2 receptor activation in a cAMP- and protein kinase (PKA) phosphorylation-dependent manner. Plays a role in maintaining the fidelity of synaptic transmission in neocortical GABAergic interneurons by generating action potential (AP) repolarization at nerve terminals, thus reducing spike-evoked calcium influx and GABA neurotransmitter release. Required for long-range synchronization of gamma oscillations over distance in the neocortex. Contributes to the modulation of the circadian rhythm of spontaneous action potential firing in suprachiasmatic nucleus (SCN) neurons in a light-dependent manner (By similarity).
Gene: KCNC2
- 分子量
- 70kDa
- 基因ID
- 3747
- UniProt
- Q96PR1
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