IL17C 抗体 (Internal Region)
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- 抗原 See all IL17C 抗体
- IL17C (Interleukin 17C (IL17C))
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抗原表位
- Internal Region
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适用
- 人, 小鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This IL17C antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
- 特异性
- IL17C Antibody detects endogenous levels of total IL17C.
- 纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- 免疫原
- A synthesized peptide derived from human IL17C, corresponding to a region within the internal amino acids.
- 亚型
- IgG
- Top Product
- Discover our top product IL17C Primary Antibody
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- 应用备注
- WB 1:1000-3000, IHC 1:200, ELISA(peptide) 1:20000-1:40000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
- 有效期
- 12 months
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- 抗原
- IL17C (Interleukin 17C (IL17C))
- 别名
- IL17C (IL17C 产品)
- 别名
- IL17C antibody, il17-3 antibody, CX2 antibody, IL-17C antibody, IL-21 antibody, interleukin 17C antibody, interleukin 17c antibody, IL17C antibody, il17c antibody, Il17c antibody
- 背景
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Description: Cytokine that plays a crucial role in innate immunity of the epithelium, including to intestinal bacterial pathogens, in an autocrine manner. Stimulates the production of antibacterial peptides and proinflammatory molecules for host defense by signaling through the NF-kappa-B and MAPK pathways. Acts synergically with IL22 in inducing the expression of antibacterial peptides, including S100A8, S100A9, REG3A and REG3G. Synergy is also observed with TNF and IL1B in inducing DEFB2 from keratinocytes. Depending on the type of insult, may have both protective and pathogenic properties, either by maintaining epithelial homeostasis after an inflammatory challenge or by promoting inflammatory phenotype. Enhanced IL17C/IL17RE signaling may also lead to greater susceptibility to autoimmune diseases.
Gene: IL17C
- 分子量
- 22 kDa
- 基因ID
- 27189
- UniProt
- Q9P0M4
- 途径
- Cellular Response to Molecule of Bacterial Origin
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