ERCC3 抗体 (N-Term)
Quick Overview for ERCC3 抗体 (N-Term) (ABIN6261590)
抗原
See all ERCC3 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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特异性
- ERCC3 Antibody detects endogenous levels of total ERCC3.
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预测反应
- Pig,Zebrafish,Bovine,Sheep,Rabbit,Dog,Chicken,Xenopus
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纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
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免疫原
- A synthesized peptide derived from human ERCC3, corresponding to a region within N-terminal amino acids.
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亚型
- IgG
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anti-DNA Repair Protein Complementing XP-B Cells (ERCC3) (C-Term) antibody
ERCC3 适用: 人 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-DNA Repair Protein Complementing XP-B Cells (ERCC3) (AA 242-261) antibodyERCC3 适用: 人 WB, ELISA, IHC, IP, IHC (p) 宿主: 小鼠 Monoclonal 3G4 unconjugated
anti-DNA Repair Protein Complementing XP-B Cells (ERCC3) (AA 513-782) antibodyERCC3 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-DNA Repair Protein Complementing XP-B Cells (ERCC3) (AA 601-700) antibodyERCC3 适用: 人, 大鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-DNA Repair Protein Complementing XP-B Cells (ERCC3) (AA 29-128) antibodyERCC3 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-DNA Repair Protein Complementing XP-B Cells (ERCC3) (N-Term) antibodyERCC3 适用: 人, Cow, 犬, 兔, 斑马鱼, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-DNA Repair Protein Complementing XP-B Cells (ERCC3) (AA 512-782) antibodyERCC3 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-DNA Repair Protein Complementing XP-B Cells (ERCC3) (N-Term) antibodyERCC3 适用: 人, 大鼠, Cow, 犬, 兔, 斑马鱼, 豚鼠, Pig, Saccharomyces cerevisiae WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
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有效期
- 12 months
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- ERCC3 (DNA Repair Protein Complementing XP-B Cells (ERCC3))
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别名
- ERCC3
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背景
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Description: ATP-dependent 3'-5' DNA helicase, component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. The ATPase activity of XPB/ERCC3, but not its helicase activity, is required for DNA opening. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. The ATP-dependent helicase activity of XPB/ERCC3 is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.
Gene: ERCC3
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分子量
- 89kDa
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基因ID
- 2071
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UniProt
- P19447
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途径
- DNA Damage Repair
抗原
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