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- 抗原 See all EPS8 抗体
- EPS8 (Epidermal Growth Factor Receptor Pathway Substrate 8 (EPS8))
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抗原表位
- Internal Region
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This EPS8 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA
- 特异性
- EPS8 Antibody detects endogenous levels of total EPS8.
- 预测反应
- Pig,Horse,Sheep,Rabbit,Dog,Xenopus
- 纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- 免疫原
- A synthesized peptide derived from human EPS8, corresponding to a region within the internal amino acids.
- 亚型
- IgG
- Top Product
- Discover our top product EPS8 Primary Antibody
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anti-Epidermal Growth Factor Receptor Pathway Substrate 8 (EPS8) (AA 9-39), (N-Term) antibody
EPS8 适用: 人 WB, IHC (p), IF, FACS 宿主: 兔 Polyclonal RB4003 unconjugated
anti-Epidermal Growth Factor Receptor Pathway Substrate 8 (EPS8) (AA 1-822) antibodyEPS8 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Epidermal Growth Factor Receptor Pathway Substrate 8 (EPS8) (C-Term) antibodyEPS8 适用: 人 WB, IHC (p), IP 宿主: 兔 Polyclonal unconjugated
anti-Epidermal Growth Factor Receptor Pathway Substrate 8 (EPS8) (AA 251-350) antibodyEPS8 适用: 人, 大鼠 ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Epidermal Growth Factor Receptor Pathway Substrate 8 (EPS8) (AA 572-670) antibodyEPS8 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Epidermal Growth Factor Receptor Pathway Substrate 8 (EPS8) (N-Term) antibodyEPS8 适用: 人 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Epidermal Growth Factor Receptor Pathway Substrate 8 (EPS8) antibodyEPS8 适用: 大鼠, 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Epidermal Growth Factor Receptor Pathway Substrate 8 (EPS8) antibodyEPS8 适用: 大鼠, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Epidermal Growth Factor Receptor Pathway Substrate 8 (EPS8) (C-Term) antibodyVerified EPS8 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 山羊 Polyclonal unconjugated
anti-Epidermal Growth Factor Receptor Pathway Substrate 8 (EPS8) (AA 647-696) antibodyEPS8 适用: 人, 大鼠, 小鼠, Pig, Cow, 猴, Hamster WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
- 有效期
- 12 months
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- 抗原
- EPS8 (Epidermal Growth Factor Receptor Pathway Substrate 8 (EPS8))
- 别名
- EPS8 (EPS8 产品)
- 别名
- AW261790 antibody, MGC81285 antibody, MGC146320 antibody, zgc:56041 antibody, epidermal growth factor receptor pathway substrate 8 antibody, epidermal growth factor receptor pathway substrate 8 L homeolog antibody, EPS8 antibody, Eps8 antibody, eps8.L antibody, eps8 antibody
- 背景
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Description: Signaling adapter that controls various cellular protrusions by regulating actin cytoskeleton dynamics and architecture. Depending on its association with other signal transducers, can regulate different processes. Together with SOS1 and ABI1, forms a trimeric complex that participates in transduction of signals from Ras to Rac by activating the Rac-specific guanine nucleotide exchange factor (GEF) activity. Acts as a direct regulator of actin dynamics by binding actin filaments and has both barbed-end actin filament capping and actin bundling activities depending on the context. Displays barbed-end actin capping activity when associated with ABI1, thereby regulating actin-based motility process: capping activity is auto-inhibited and inhibition is relieved upon ABI1 interaction. Also shows actin bundling activity when associated with BAIAP2, enhancing BAIAP2-dependent membrane extensions and promoting filopodial protrusions. Involved in the regulation of processes such as axonal filopodia growth, stereocilia length, dendritic cell migration and cancer cell migration and invasion. Acts as a regulator of axonal filopodia formation in neurons: in the absence of neurotrophic factors, negatively regulates axonal filopodia formation via actin-capping activity. In contrast, it is phosphorylated in the presence of BDNF leading to inhibition of its actin-capping activity and stimulation of filopodia formation. Component of a complex with WHRN and MYO15A that localizes at stereocilia tips and is required for elongation of the stereocilia actin core. Indirectly involved in cell cycle progression, its degradation following ubiquitination being required during G2 phase to promote cell shape changes.
Gene: EPS8
- 分子量
- 92 kDa
- 基因ID
- 2059
- UniProt
- Q12929
- 途径
- EGFR Signaling Pathway, Regulation of Actin Filament Polymerization
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