EIF4A3 抗体 (Internal Region)
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- 抗原 See all EIF4A3 抗体
- EIF4A3 (Eukaryotic Translation Initiation Factor 4A3 (EIF4A3))
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抗原表位
- Internal Region
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适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This EIF4A3 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
- 特异性
- EIF4A3 Antibody detects endogenous levels of total eIF4A3.
- 预测反应
- Pig,Zebrafish,Bovine,Horse,Sheep,Dog,Chicken
- 纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- 免疫原
- A synthesized peptide derived from human eIF4A3, corresponding to a region within the internal amino acids.
- 亚型
- IgG
- Top Product
- Discover our top product EIF4A3 Primary Antibody
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anti-Eukaryotic Translation Initiation Factor 4A3 (EIF4A3) (AA 6-166) antibody
EIF4A3 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Eukaryotic Translation Initiation Factor 4A3 (EIF4A3) antibodyEIF4A3 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Eukaryotic Translation Initiation Factor 4A3 (EIF4A3) (AA 351-411) antibodyEIF4A3 适用: 人, 小鼠, 大鼠 WB, ELISA, IF (cc), IF (p), IHC (p), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Eukaryotic Translation Initiation Factor 4A3 (EIF4A3) (AA 1-210) antibodyEIF4A3 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Eukaryotic Translation Initiation Factor 4A3 (EIF4A3) (AA 312-411) antibodyEIF4A3 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Eukaryotic Translation Initiation Factor 4A3 (EIF4A3) (AA 136-185) antibodyEIF4A3 适用: 人, 小鼠, 大鼠, 犬, 斑马鱼, Cow, 豚鼠, 马, 小鸡, Pig, 非洲爪蟾, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Eukaryotic Translation Initiation Factor 4A3 (EIF4A3) (AA 51-100) antibodyEIF4A3 适用: 人, 小鼠, 大鼠, 犬, 斑马鱼, Cow, 豚鼠, 马, 小鸡, Pig, 非洲爪蟾 WB 宿主: 兔 Polyclonal unconjugated
anti-Eukaryotic Translation Initiation Factor 4A3 (EIF4A3) (AA 1-50) antibodyEIF4A3 适用: 人, 小鼠, 大鼠, 犬, Cow, 豚鼠, 马, Pig IHC, IP, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Eukaryotic Translation Initiation Factor 4A3 (EIF4A3) (AA 125-175) antibodyEIF4A3 适用: 人, 小鼠, 大鼠, 斑马鱼, 小鸡, 非洲爪蟾 WB, IHC, IP, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
- 有效期
- 12 months
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- 抗原
- EIF4A3 (Eukaryotic Translation Initiation Factor 4A3 (EIF4A3))
- 别名
- EIF4A3 (EIF4A3 产品)
- 别名
- DDX48 antibody, NMP265 antibody, NUK34 antibody, eIF4AIII antibody, 2400003O03Rik antibody, Ddx48 antibody, eIF4A-III antibody, mKIAA0111 antibody, ddx48 antibody, nuk34 antibody, nmp265 antibody, eif4aiii antibody, EIF4A3 antibody, eif4a3 antibody, zgc:56139 antibody, XeIF-4AIII antibody, eif4a3-B antibody, eukaryotic translation initiation factor 4A3 antibody, eukaryotic initiation factor 4A-III antibody, eukaryotic translation initiation factor 4A3 S homeolog antibody, Eukaryotic initiation factor 4A-III antibody, EIF4A3 antibody, Eif4a3 antibody, eif4a3 antibody, LOC100185906 antibody, eif4a3.S antibody, if4a3 antibody
- 背景
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Description: ATP-dependent RNA helicase (PubMed:16170325). Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:22961380, PubMed:28502770, PubMed:28076346). Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Its RNA-dependent ATPase and RNA-helicase activities are induced by CASC3, but abolished in presence of the MAGOH-RBM8A heterodimer, thereby trapping the ATP-bound EJC core onto spliced mRNA in a stable conformation. The inhibition of ATPase activity by the MAGOH-RBM8A heterodimer increases the RNA-binding affinity of the EJC. Involved in translational enhancement of spliced mRNAs after formation of the 80S ribosome complex. Binds spliced mRNA in sequence-independent manner, 20-24 nucleotides upstream of mRNA exon-exon junctions. Shows higher affinity for single-stranded RNA in an ATP-bound core EJC complex than after the ATP is hydrolyzed. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes), specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S), the function is different from the established EJC assembly (PubMed:22203037). Involved in craniofacial development (PubMed:24360810).
Gene: EIF4A3
- 分子量
- 47 kDa
- 基因ID
- 9775
- UniProt
- P38919
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