DYRK3 抗体 (Internal Region)
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- 抗原 See all DYRK3 抗体
- DYRK3 (Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 3 (DYRK3))
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抗原表位
- Internal Region
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适用
- 人, 大鼠, 小鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This DYRK3 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
- 特异性
- DYRK3 Antibody detects endogenous levels of total DYRK3.
- 预测反应
- Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog
- 纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- 免疫原
- A synthesized peptide derived from human DYRK3, corresponding to a region within the internal amino acids.
- 亚型
- IgG
- Top Product
- Discover our top product DYRK3 Primary Antibody
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anti-Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 3 (DYRK3) (AA 1-568) antibody
DYRK3 适用: 人 ELISA, IHC (p) 宿主: 小鼠 Monoclonal 3E10 unconjugated
anti-Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 3 (DYRK3) antibodyDYRK3 适用: 人, 大鼠, 小鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 3 (DYRK3) antibodyDYRK3 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 3 (DYRK3) (N-Term) antibodyDYRK3 适用: 人, 小鼠 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 3 (DYRK3) (AA 1-300) antibodyDYRK3 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 3 (DYRK3) (AA 1-569) antibodyDYRK3 适用: 人 ELISA 宿主: 小鼠 Monoclonal 3E10 unconjugated
anti-Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 3 (DYRK3) (AA 71-120) antibodyDYRK3 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 3 (DYRK3) (AA 35-84) antibodyDYRK3 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB 1:1000-3000, IHC 1:200, ELISA(peptide) 1:20000-1:40000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
- 有效期
- 12 months
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- 抗原
- DYRK3 (Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 3 (DYRK3))
- 别名
- DYRK3 (DYRK3 产品)
- 别名
- DYRK5 antibody, RED antibody, REDK antibody, hYAK3-2 antibody, BC006704 antibody, DYRK3 antibody, MGC89944 antibody, dual specificity tyrosine phosphorylation regulated kinase 3 antibody, dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 antibody, dual specificity tyrosine-(Y)-phosphorylation regulated kinase 3 antibody, dual specificity tyrosine-(Y)-phosphorylation regulated kinase 3 L homeolog antibody, DYRK3 antibody, Dyrk3 antibody, dyrk3 antibody, dyrk3.L antibody
- 背景
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Description: Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. Negative regulator of EPO-dependent erythropoiesis, may place an upper limit on red cell production during stress erythropoiesis. Inhibits cell death due to cytokine withdrawal in hematopoietic progenitor cells (PubMed:10779429). May act by regulating CREB/CRE signaling (By similarity). Stabilizes and prevents stress granule disassembly thereby regulating mTORC1 signaling during cellular stress. During stressful conditions, DYRK3 partitions to the stress granule from the cytosol, as well as mTORC1 components, which prevents mTORC1 signaling. When stress signals are gone, the kinase activity of DYRK3 is required for the dissolution of stress granule and mTORC1 relocation to the cytosol, and promotes the phosphorylation of the mTORC1 inhibitor, AKT1S1, allowing full reactivation of mTORC1 signaling (PubMed:23415227). Promotes cell survival upon genotoxic stress through phosphorylation of SIRT1. This in turn inhibits TP53 activity and apoptosis (PubMed:20167603).
Gene: DYRK3
- 分子量
- 66 kDa
- 基因ID
- 8444
- UniProt
- O43781
- 途径
- Negative Regulation of Hormone Secretion, Regulation of Lipid Metabolism by PPARalpha
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