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- 抗原 See all SHFM1 抗体
- SHFM1 (Split Hand/foot Malformation (Ectrodactyly) Type 1 (SHFM1))
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适用
- 人, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This SHFM1 antibody is un-conjugated
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应用范围
- Immunohistochemistry (IHC), Western Blotting (WB)
- 特异性
- DSS1 antibody detects endogenous levels of DSS1.
- 交叉反应
- 人, 大鼠
- 纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- 免疫原
- A synthesized peptide derived from human DSS1.
- 亚型
- IgG
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- 应用备注
- WB 1:500-1:2000, IHC 1:50-1:200
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20 °C.Stable for 12 months from date of receipt
- 有效期
- 12 months
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- 抗原
- SHFM1 (Split Hand/foot Malformation (Ectrodactyly) Type 1 (SHFM1))
- 别名
- DSS1 (SHFM1 产品)
- 别名
- DSS1 antibody, ECD antibody, SEM1 antibody, SHFD1 antibody, SHSF1 antibody, Shfdg1 antibody, Shfg antibody, Dss1 antibody, SHFM1 antibody, dss1 antibody, ecd antibody, sem1 antibody, shfd1 antibody, shfdg1 antibody, shfm1 antibody, shfm1.S antibody, shsf1 antibody, wu:fb55c02 antibody, zgc:56203 antibody, zgc:85901 antibody, SEM1, 26S proteasome complex subunit antibody, SEM1, 26S proteasome complex subunit S homeolog antibody, SEM1 antibody, Sem1 antibody, sem1.S antibody, sem1 antibody
- 背景
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Description: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair (PubMed:15117943). Component of the TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, SEM1, and either centrin CETN2 or CETN3 (PubMed:22307388). The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery. Binds and stabilizes BRCA2 and is thus involved in the control of R-loop-associated DNA damage and thus transcription-associated genomic instability. R-loop accumulation increases in SEM1-depleted cells.
Gene: SEM1
- 分子量
- 8-10 kDa
- 基因ID
- 7979
- UniProt
- P60896
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