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- 抗原 See all DCLRE1B 抗体
- DCLRE1B (DNA Cross-Link Repair 1B (DCLRE1B))
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抗原表位
- Internal Region
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This DCLRE1B antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA
- 特异性
- DCLRE1B Antibody detects endogenous levels of total DCLRE1B.
- 预测反应
- Pig,Bovine,Horse,Sheep
- 纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- 免疫原
- A synthesized peptide derived from human DCLRE1B, corresponding to a region within the internal amino acids.
- 亚型
- IgG
- Top Product
- Discover our top product DCLRE1B Primary Antibody
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anti-DNA Cross-Link Repair 1B (DCLRE1B) (AA 208-236) antibody
DCLRE1B 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB26835 unconjugated
anti-DNA Cross-Link Repair 1B (DCLRE1B) (C-Term) antibodyDCLRE1B 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-DNA Cross-Link Repair 1B (DCLRE1B) (AA 345-493) antibodyDCLRE1B 适用: 人 ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-DNA Cross-Link Repair 1B (DCLRE1B) antibodyDCLRE1B 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-DNA Cross-Link Repair 1B (DCLRE1B) (AA 323-532) antibodyDCLRE1B 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
- 有效期
- 12 months
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- 抗原
- DCLRE1B (DNA Cross-Link Repair 1B (DCLRE1B))
- 别名
- DCLRE1B (DCLRE1B 产品)
- 别名
- APOLLO antibody, SNM1B antibody, SNMIB antibody, im:6894074 antibody, zgc:154089 antibody, AI452214 antibody, Apollo antibody, mSNM1B antibody, DNA cross-link repair 1B antibody, DCLRE1B antibody, Dclre1b antibody, dclre1b antibody
- 背景
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Description: 5'-3' exonuclease that plays a central role in telomere maintenance and protection during S-phase. Participates in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair, thereby ensuring that telomeres do not fuse. Plays a key role in telomeric loop (T loop) formation by being recruited by TERF2 at the leading end telomeres and by processing leading-end telomeres immediately after their replication via its exonuclease activity: generates 3' single-stranded overhang at the leading end telomeres avoiding blunt leading-end telomeres that are vulnerable to end-joining reactions and expose the telomere end in a manner that activates the DNA repair pathways. Together with TERF2, required to protect telomeres from replicative damage during replication by controlling the amount of DNA topoisomerase (TOP1, TOP2A and TOP2B) needed for telomere replication during fork passage and prevent aberrant telomere topology. Also involved in response to DNA damage: plays a role in response to DNA interstrand cross-links (ICLs) by facilitating double-strand break formation. In case of spindle stress, involved in prophase checkpoint.
Gene: DCLRE1B
- 分子量
- 60 kDa
- 基因ID
- 64858
- UniProt
- Q9H816
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