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- 抗原 See all CPSF6 抗体
- CPSF6 (Cleavage and Polyadenylation Specific Factor 6, 68kDa (CPSF6))
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抗原表位
- Internal Region
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适用
- 人, 小鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This CPSF6 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA
- 特异性
- CPSF6 Antibody detects endogenous levels of total CPSF6.
- 预测反应
- Bovine,Horse,Dog
- 纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- 免疫原
- A synthesized peptide derived from human CPSF6, corresponding to a region within the internal amino acids.
- 亚型
- IgG
- Top Product
- Discover our top product CPSF6 Primary Antibody
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anti-Cleavage and Polyadenylation Specific Factor 6, 68kDa (CPSF6) (AA 37-136) antibody
CPSF6 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 3F11 unconjugated
anti-Cleavage and Polyadenylation Specific Factor 6, 68kDa (CPSF6) antibodyCPSF6 适用: 人 WB, IHC, IF, IP 宿主: 兔 Polyclonal unconjugated
anti-Cleavage and Polyadenylation Specific Factor 6, 68kDa (CPSF6) (AA 186-226) antibodyCPSF6 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Cleavage and Polyadenylation Specific Factor 6, 68kDa (CPSF6) (AA 37-136) antibodyCPSF6 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 1C5 unconjugated
anti-Cleavage and Polyadenylation Specific Factor 6, 68kDa (CPSF6) (AA 261-310) antibodyCPSF6 适用: 人 WB, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Cleavage and Polyadenylation Specific Factor 6, 68kDa (CPSF6) (Middle Region) antibodyCPSF6 适用: 人, 小鼠, 大鼠, 犬, Cow, 豚鼠, 兔, 马, 斑马鱼 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Cleavage and Polyadenylation Specific Factor 6, 68kDa (CPSF6) (AA 261-310) antibodyCPSF6 适用: 人, 小鼠, 大鼠, 犬, Cow, 豚鼠, 兔, 马, 斑马鱼, Pig, 小鸡, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Cleavage and Polyadenylation Specific Factor 6, 68kDa (CPSF6) (AA 23-51), (N-Term) antibodyCPSF6 适用: 人 WB 宿主: 兔 Polyclonal RB42780 unconjugated
anti-Cleavage and Polyadenylation Specific Factor 6, 68kDa (CPSF6) antibodyCPSF6 适用: 人, 小鼠, 大鼠 IF 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
- 有效期
- 12 months
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- 抗原
- CPSF6 (Cleavage and Polyadenylation Specific Factor 6, 68kDa (CPSF6))
- 别名
- CPSF6 (CPSF6 产品)
- 别名
- CPSF6 antibody, wu:fa22f12 antibody, zgc:85819 antibody, 4733401N12Rik antibody, AI256641 antibody, CFIM antibody, CFIM68 antibody, HPBRII-4 antibody, HPBRII-7 antibody, cleavage and polyadenylation specific factor 6 antibody, cleavage and polyadenylation specific factor 6 S homeolog antibody, CPSF6 antibody, cpsf6.S antibody, cpsf6 antibody, Cpsf6 antibody
- 背景
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Description: Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs (PubMed:9659921, PubMed:8626397, PubMed:14690600, PubMed:29276085). CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals) (PubMed:9659921, PubMed:8626397, PubMed:14690600). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation (PubMed:23187700, PubMed:29276085). The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs (PubMed:20695905, PubMed:29276085). CPSF6 enhances NUDT21/CPSF5 binding to 5'-UGUA-3' elements localized upstream of pA signals and promotes RNA looping, and hence activates directly the mRNA 3'-processing machinery (PubMed:15169763, PubMed:29276085, PubMed:21295486). Plays a role in mRNA export (PubMed:19864460).
Gene: CPSF6
- 分子量
- 59 kDa
- 基因ID
- 11052
- UniProt
- Q16630
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