C9ORF72 抗体 (Internal Region)
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- 抗原 See all C9ORF72 抗体
- C9ORF72 (Chromosome 9 Open Reading Frame 72 (C9ORF72))
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抗原表位
- Internal Region
- 适用
- 人, 大鼠, 小鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This C9ORF72 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC)
- 特异性
- C9orf72 Antibody detects endogenous levels of total C9orf72.
- 预测反应
- Pig,Sheep,Rabbit
- 纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- 免疫原
- A synthesized peptide derived from human C9orf72, corresponding to a region within the internal amino acids.
- 亚型
- IgG
- Top Product
- Discover our top product C9ORF72 Primary Antibody
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anti-Chromosome 9 Open Reading Frame 72 (C9ORF72) (AA 1-230) antibody
C9ORF72 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Chromosome 9 Open Reading Frame 72 (C9ORF72) (AA 391-481) antibodyC9ORF72 适用: 人, 大鼠, 小鼠 WB, ELISA, FACS, IF (cc), IF (p), IHC (p), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Chromosome 9 Open Reading Frame 72 (C9ORF72) (AA 138-430) antibodyC9ORF72 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Chromosome 9 Open Reading Frame 72 (C9ORF72) (AA 396-424), (C-Term) antibodyC9ORF72 适用: 人 WB 宿主: 兔 Polyclonal RB27382 unconjugated
anti-Chromosome 9 Open Reading Frame 72 (C9ORF72) (AA 1-481) antibodyC9ORF72 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Chromosome 9 Open Reading Frame 72 (C9ORF72) (AA 396-424) antibodyC9ORF72 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB 1:500-1:2000, IHC 1:50-1:200
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
- 有效期
- 12 months
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- 抗原
- C9ORF72 (Chromosome 9 Open Reading Frame 72 (C9ORF72))
- 别名
- C9orf72 (C9ORF72 产品)
- 别名
- CZH9orf72 antibody, ALSFTD antibody, FTDALS antibody, AI840585 antibody, c9orf72 antibody, chromosome Z C9orf72 homolog antibody, chromosome 9 open reading frame 72 antibody, RIKEN cDNA 3110043O21 gene antibody, similar to RIKEN cDNA 3110043O21 antibody, chromosome 9 open reading frame 72 L homeolog antibody, CZH9orf72 antibody, C9orf72 antibody, 3110043O21Rik antibody, RGD1359108 antibody, c9orf72.L antibody
- 背景
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Description: Component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy (PubMed:27193190, PubMed:27103069, PubMed:27617292, PubMed:28195531). In the complex, C9orf72 and SMCR8 probably constitute the catalytic subunits that promote the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation (PubMed:27103069). The C9orf72-SMCR8 complex also acts as a regulator of autophagy initiation by interacting with the ATG1/ULK1 kinase complex and modulating its protein kinase activity (PubMed:27617292). Positively regulates initiation of autophagy by regulating the RAB1A-dependent trafficking of the ATG1/ULK1 kinase complex to the phagophore which leads to autophagosome formation (PubMed:27334615). Acts as a regulator of mTORC1 signaling by promoting phosphorylation of mTORC1 substrates (PubMed:27559131). Plays a role in endosomal trafficking (PubMed:24549040). May be involved in regulating the maturation of phagosomes to lysosomes (By similarity). Regulates actin dynamics in motor neurons by inhibiting the GTP-binding activity of ARF6, leading to ARF6 inactivation (PubMed:27723745). This reduces the activity of the LIMK1 and LIMK2 kinases which are responsible for phosphorylation and inactivation of cofilin, leading to cofilin activation (PubMed:27723745). Positively regulates axon extension and axon growth cone size in spinal motor neurons (PubMed:27723745). Plays a role within the hematopoietic system in restricting inflammation and the development of autoimmunity (By similarity).
Gene: C9orf72
- 分子量
- 50-54 kDa,25-30 kDa
- 基因ID
- 203228
- UniProt
- Q96LT7
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