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ALKBH7 抗体

ALKBH7 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN6259889
发货至: 中国
  • 抗原 See all ALKBH7 抗体
    ALKBH7 (AlkB, Alkylation Repair Homolog 7 (ALKBH7))
    适用
    • 10
    • 8
    • 1
    人, 小鼠
    宿主
    • 10
    克隆类型
    • 10
    多克隆
    标记
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This ALKBH7 antibody is un-conjugated
    应用范围
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
    特异性
    ALKBH7 Antibody detects endogenous levels of total ALKBH7
    交叉反应
    人, 小鼠
    纯化方法
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    免疫原
    A synthesized peptide derived from human ALKBH7
    亚型
    IgG
    Top Product
    Discover our top product ALKBH7 Primary Antibody
  • 应用备注
    WB 1:1000-3000 IHC 1:200
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 mg/mL
    缓冲液
    Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20 °C.Stable for 12 months from date of receipt
    有效期
    12 months
  • 抗原
    ALKBH7 (AlkB, Alkylation Repair Homolog 7 (ALKBH7))
    别名
    ALKBH7 (ALKBH7 产品)
    别名
    ABH7 antibody, SPATA11 antibody, UNQ6002 antibody, 2310045B01Rik antibody, 2510008E23Rik antibody, Abh7 antibody, Spata11 antibody, alkB homolog 7 antibody, Alkbh7 antibody, ALKBH7 antibody
    背景

    Description: May function as protein hydroxylase, can catalyze auto-hydroxylation at Leu-110 (in vitro), but this activity may be due to the absence of the true substrate (PubMed:25122757). Required to induce programmed necrosis in response to DNA damage caused by cytotoxic alkylating agents. Acts by triggering the collapse of mitochondrial membrane potential and loss of mitochondrial function that leads to energy depletion and cell death (PubMed:23666923). ALKBH7-mediated necrosis is probably required to prevent the accumulation of cells with DNA damage (PubMed:23666923). Does not display DNA demethylase activity (PubMed:23666923). Involved in fatty acid metabolism (By similarity).

    Gene: ALKBH7

    分子量
    24 kDa
    基因ID
    84266
    UniProt
    Q9BT30
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