Actin-Like 6B 抗体 (Internal Region)
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- 抗原 See all Actin-Like 6B (ACTL6B) 抗体
- Actin-Like 6B (ACTL6B)
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抗原表位
- Internal Region
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适用
- 人, 小鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This Actin-Like 6B antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
- 特异性
- ACTL6B Antibody detects endogenous levels of total ACTL6B.
- 预测反应
- Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken
- 纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- 免疫原
- A synthesized peptide derived from human ACTL6B, corresponding to a region within the internal amino acids.
- 亚型
- IgG
- Top Product
- Discover our top product ACTL6B Primary Antibody
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anti-Actin-Like 6B (ACTL6B) (AA 1-280) antibody
ACTL6B 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Actin-Like 6B (ACTL6B) (AA 1-280) antibodyACTL6B 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Actin-Like 6B (ACTL6B) antibodyACTL6B 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Actin-Like 6B (ACTL6B) (AA 42-70), (N-Term) antibodyACTL6B 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB26766 unconjugated
anti-Actin-Like 6B (ACTL6B) antibodyACTL6B 适用: 人, 小鼠, 大鼠 WB, IHC, IF, IC 宿主: 兔 Polyclonal unconjugated
anti-Actin-Like 6B (ACTL6B) (N-Term) antibodyACTL6B 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Actin-Like 6B (ACTL6B) (AA 178-452) antibodyACTL6B 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Actin-Like 6B (ACTL6B) (AA 323-372) antibodyACTL6B 适用: 人, 小鼠, 大鼠, Cow, 犬, 豚鼠, 马, 兔, Bat, 猴, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-Actin-Like 6B (ACTL6B) (AA 42-70) antibodyACTL6B 适用: 人 WB, IHC, FACS, IHC (p) 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB 1:1000-3000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
- 有效期
- 12 months
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- 抗原
- Actin-Like 6B (ACTL6B)
- 别名
- ACTL6B (ACTL6B 产品)
- 别名
- MGC110167 antibody, zgc:110167 antibody, ACTL6 antibody, BAF53B antibody, Actl6 antibody, ArpNa antibody, Baf53b antibody, actin-like 6B antibody, actin like 6B antibody, actl6b antibody, ACTL6B antibody, Actl6b antibody
- 背景
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Description: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Belongs to the neuron-specific chromatin remodeling complex (nBAF complex), as such plays a role in remodeling mononucleosomes in an ATP-dependent fashion, and is required for postmitotic neural development and dendritic outgrowth. During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. ACTL6B/BAF53B is not essential for assembly of the nBAF complex but is required for targeting the complex and CREST to the promoter of genes essential for dendritic growth (By similarity).
Gene: ACTL6B
- 分子量
- 47 kDa
- 基因ID
- 51412
- UniProt
- O94805
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