ZFP36L2 抗体 (Internal Region)
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- 抗原 See all ZFP36L2 抗体
- ZFP36L2 (Zinc Finger Protein 36, C3H Type-Like 2 (ZFP36L2))
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抗原表位
- Internal Region
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适用
- 人, 小鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This ZFP36L2 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)
- 特异性
- TISD Antibody detects endogenous levels of total TISD.
- 预测反应
- Pig,Bovine,Rabbit,Dog,Chicken,Xenopus
- 纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- 免疫原
- A synthesized peptide derived from human TISD, corresponding to a region within the internal amino acids.
- 亚型
- IgG
- Top Product
- Discover our top product ZFP36L2 Primary Antibody
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anti-Zinc Finger Protein 36, C3H Type-Like 2 (ZFP36L2) antibody
ZFP36L2 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Zinc Finger Protein 36, C3H Type-Like 2 (ZFP36L2) (N-Term) antibodyZFP36L2 适用: 人, 小鼠, 大鼠, Cow, 犬, 马, Pig, 兔 WB 宿主: 兔 Polyclonal unconjugated
anti-Zinc Finger Protein 36, C3H Type-Like 2 (ZFP36L2) (AA 219-321) antibodyZFP36L2 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Zinc Finger Protein 36, C3H Type-Like 2 (ZFP36L2) (N-Term) antibodyZFP36L2 适用: 人, 小鼠, 大鼠, Cow, 犬, 马, Bat, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Zinc Finger Protein 36, C3H Type-Like 2 (ZFP36L2) (AA 207-256) antibodyZFP36L2 适用: 人, 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Zinc Finger Protein 36, C3H Type-Like 2 (ZFP36L2) (AA 166-193) antibodyZFP36L2 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB37481 unconjugated
anti-Zinc Finger Protein 36, C3H Type-Like 2 (ZFP36L2) (N-Term) antibodyZFP36L2 适用: 小鼠, 大鼠, Cow, 豚鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Zinc Finger Protein 36, C3H Type-Like 2 (ZFP36L2) antibodyZFP36L2 适用: 人, 小鼠, Cow WB, IHC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
- 有效期
- 12 months
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- 抗原
- ZFP36L2 (Zinc Finger Protein 36, C3H Type-Like 2 (ZFP36L2))
- 别名
- ZFP36L2 (ZFP36L2 产品)
- 别名
- BRF2 antibody, ERF-2 antibody, ERF2 antibody, RNF162C antibody, TIS11D antibody, Brf2 antibody, Tis11d antibody, fi22c11 antibody, wu:fi22c11 antibody, zgc:76924 antibody, ZFP36L2 antibody, XC3H-3 antibody, XC3H-3b antibody, c3h-3 antibody, zfp36l2 antibody, brf2 antibody, erf-2 antibody, erf2 antibody, rnf162c antibody, tis11d antibody, cb198 antibody, cb480 antibody, fk89d11 antibody, id:ibd1247 antibody, sb:cb198 antibody, sb:cb480 antibody, wu:fb80h11 antibody, wu:fb92f07 antibody, wu:fk89d11 antibody, zfp36l1 antibody, zgc:153979 antibody, XC3H-2 antibody, berg36 antibody, brf1 antibody, c3h-2 antibody, cmg1 antibody, erf-1 antibody, erf1 antibody, rnf162b antibody, tis11b antibody, zfp36l1-a antibody, zfp36l1-b antibody, ZFP36 ring finger protein like 2 antibody, zinc finger protein 36, C3H type-like 2 antibody, ZFP36 ring finger protein-like 2 S homeolog antibody, ZFP36 ring finger protein-like 2 L homeolog antibody, ZFP36 ring finger protein-like 2 antibody, zinc finger protein 36, C3H type-like 1a antibody, ZFP36 ring finger protein-like 1 L homeolog antibody, ZFP36L2 antibody, Zfp36l2 antibody, zfp36l2 antibody, zfp36l2.S antibody, zfp36l2.L antibody, zfp36l1a antibody, zfp36l1.L antibody
- 背景
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Description: Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PubMed:25106868, PubMed:14981510). Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (PubMed:25106868). Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes (PubMed:25106868). Binds to 3'-UTR ARE of numerous mRNAs (PubMed:20506496, PubMed:25106868, PubMed:14981510). Promotes ARE-containing mRNA decay of the low-density lipoprotein (LDL) receptor (LDLR) mRNA in response to phorbol 12-myristate 13-acetate (PMA) treatment in a p38 MAPK-dependent manner (PubMed:25106868). Positively regulates early adipogenesis by promoting ARE-mediated mRNA decay of immediate early genes (IEGs). Plays a role in mature peripheral neuron integrity by promoting ARE-containing mRNA decay of the transcriptional repressor REST mRNA. Plays a role in ovulation and oocyte meiotic maturation by promoting ARE-mediated mRNA decay of the luteinizing hormone receptor LHCGR mRNA. Acts as a negative regulator of erythroid cell differentiation: promotes glucocorticoid-induced self-renewal of erythroid cells by binding mRNAs that are induced or highly expressed during terminal erythroid differentiation and promotes their degradation, preventing erythroid cell differentiation. In association with ZFP36L1 maintains quiescence on developing B lymphocytes by promoting ARE-mediated decay of several mRNAs encoding cell cycle regulators that help B cells progress through the cell cycle, and hence ensuring accurate variable-diversity-joining (VDJ) recombination process and functional immune cell formation. Together with ZFP36L1 is also necessary for thymocyte development and prevention of T-cell acute lymphoblastic leukemia (T-ALL) transformation by promoting ARE-mediated mRNA decay of the oncogenic transcription factor NOTCH1 mRNA.
Gene: ZFP36L2
- 分子量
- 40 kDa
- 基因ID
- 678
- UniProt
- P47974
- 途径
- Stem Cell Maintenance
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