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- 抗原 See all UBE2D3 抗体
- UBE2D3 (Ubiquitin-Conjugating Enzyme E2D 3 (UBE2D3))
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适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This UBE2D3 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA
- 特异性
- UBE2D3 antibody detects endogenous levels of total UBE2D3
- 交叉反应
- 人, 小鼠, 大鼠
- 纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- 免疫原
- A synthesized peptide
- 亚型
- IgG
- Top Product
- Discover our top product UBE2D3 Primary Antibody
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anti-Ubiquitin-Conjugating Enzyme E2D 3 (UBE2D3) (N-Term) antibody
UBE2D3 适用: 人, 小鼠, 大鼠, Cow, 犬, 豚鼠, 马, 兔, Saccharomyces cerevisiae, 斑马鱼 WB 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin-Conjugating Enzyme E2D 3 (UBE2D3) (AA 1-147) antibodyUBE2D3 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 4C1-1E3 unconjugated
anti-Ubiquitin-Conjugating Enzyme E2D 3 (UBE2D3) (AA 1-147) antibodyUBE2D3 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin-Conjugating Enzyme E2D 3 (UBE2D3) antibodyUBE2D3 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin-Conjugating Enzyme E2D 3 (UBE2D3) (N-Term) antibodyUBE2D3 适用: 人, 小鼠, 大鼠, Cow, 犬, 豚鼠, 马, 小鸡, Hamster, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin-Conjugating Enzyme E2D 3 (UBE2D3) (AA 1-100) antibodyUBE2D3 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin-Conjugating Enzyme E2D 3 (UBE2D3) (AA 109-136), (C-Term) antibodyUBE2D3 适用: 人 WB 宿主: 兔 Polyclonal RB36300 unconjugated
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- 应用备注
- WB 1:500-1:2000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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- 抗原
- UBE2D3 (Ubiquitin-Conjugating Enzyme E2D 3 (UBE2D3))
- 别名
- UBE2D3 (UBE2D3 产品)
- 别名
- E2(17)KB3 antibody, UBC4/5 antibody, UBCH5C antibody, eff antibody, fb36f02 antibody, wu:fb36f02 antibody, zgc:56340 antibody, 1100001F19Rik antibody, 9430029A22Rik antibody, AA414951 antibody, UBE2D3P antibody, Xubc4 antibody, e2(17)kb3 antibody, ubc4/5 antibody, ubch5c antibody, ube2d3.1 antibody, ube2d2 antibody, xubc4 antibody, wu:fj13d01 antibody, zgc:73200 antibody, ubiquitin conjugating enzyme E2 D3 antibody, ubiquitin-conjugating enzyme E2D 3 antibody, ubiquitin conjugating enzyme E2 D3 L homeolog antibody, ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast), like antibody, UBE2D3 antibody, ube2d3 antibody, Ube2d3 antibody, LOC100223566 antibody, ube2d3.L antibody, ube2d2l antibody
- 背景
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Description: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'-linked polyubiquitination. Cooperates with the E2 CDC34 and the SCF(FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal degradation. Acts as an initiator E2, priming the phosphorylated NFKBIA target at positions 'Lys-21' and/or 'Lys-22' with a monoubiquitin. Ubiquitin chain elongation is then performed by CDC34, building ubiquitin chains from the UBE2D3-primed NFKBIA-linked ubiquitin. Acts also as an initiator E2, in conjunction with RNF8, for the priming of PCNA. Monoubiquitination of PCNA, and its subsequent polyubiquitination, are essential events in the operation of the DNA damage tolerance (DDT) pathway that is activated after DNA damage caused by UV or chemical agents during S-phase. Associates with the BRCA1/BARD1 E3 ligase complex to perform ubiquitination at DNA damage sites following ionizing radiation leading to DNA repair. Targets DAPK3 for ubiquitination which influences promyelocytic leukemia protein nuclear body (PML-NB) formation in the nucleus. In conjunction with the MDM2 and TOPORS E3 ligases, functions ubiquitination of p53/TP53. Supports NRDP1-mediated ubiquitination and degradation of ERBB3 and of BRUCE which triggers apoptosis. In conjunction with the CBL E3 ligase, targets EGFR for polyubiquitination at the plasma membrane as well as during its internalization and transport on endosomes. In conjunction with the STUB1 E3 quality control E3 ligase, ubiquitinates unfolded proteins to catalyze their immediate destruction.
Gene: UBE2D3
- 分子量
- 17 kDa
- 基因ID
- 7323
- UniProt
- P61077
- 途径
- Activation of Innate immune Response, Toll-Like Receptors Cascades
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