PIP5K1C 抗体 (Internal Region)
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- 抗原 See all PIP5K1C 抗体
- PIP5K1C (Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, gamma (PIP5K1C))
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抗原表位
- Internal Region
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This PIP5K1C antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)
- 特异性
- PIP5K1C Antibody detects endogenous levels of total PIP5K1C.
- 预测反应
- Pig,Bovine,Sheep,Dog,Chicken
- 纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- 免疫原
- A synthesized peptide derived from human PIP5K1C, corresponding to a region within the internal amino acids.
- 亚型
- IgG
- Top Product
- Discover our top product PIP5K1C Primary Antibody
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anti-Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, gamma (PIP5K1C) antibody
PIP5K1C 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, gamma (PIP5K1C) (AA 637-668), (C-Term) antibodyPIP5K1C 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB01733 unconjugated
anti-Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, gamma (PIP5K1C) (AA 561-667) antibodyPIP5K1C 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 7D11 unconjugated
anti-Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, gamma (PIP5K1C) (AA 561-667) antibodyPIP5K1C 适用: 人 WB, ELISA, IP 宿主: 小鼠 Monoclonal 2E9 unconjugated
anti-Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, gamma (PIP5K1C) (AA 26-57), (N-Term) antibodyPIP5K1C 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB01732 unconjugated
anti-Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, gamma (PIP5K1C) antibodyPIP5K1C 适用: 人, 小鼠, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, gamma (PIP5K1C) (AA 1-206) antibodyPIP5K1C 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, gamma (PIP5K1C) (C-Term) antibodyPIP5K1C 适用: 人 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
- 有效期
- 12 months
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- 抗原
- PIP5K1C (Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, gamma (PIP5K1C))
- 别名
- PIP5K1C (PIP5K1C 产品)
- 别名
- LCCS3 antibody, PIP5K-GAMMA antibody, PIP5Kgamma antibody, PIPKIg_v4 antibody, MGC130766 antibody, PIP5K1C antibody, AI115456 antibody, AI835305 antibody, Pip5kIgamma antibody, phosphatidylinositol-4-phosphate 5-kinase type 1 gamma antibody, phosphatidylinositol-4-phosphate 5-kinase, type I, gamma S homeolog antibody, phosphatidylinositol-4-phosphate 5-kinase, type I, gamma antibody, phosphatidylinositol-4-phosphate 5-kinase, type 1 gamma antibody, PIP5K1C antibody, Pip5k1c antibody, pip5k1c.S antibody, pip5k1c antibody
- 背景
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Description: Catalyzes the phosphorylation of phosphatidylinositol 4-phosphate (PtdIns4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). PtdIns(4,5)P2 is involved in a variety of cellular processes and is the substrate to form phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3), another second messenger. The majority of PtdIns(4,5)P2 is thought to occur via type I phosphatidylinositol 4-phosphate 5-kinases given the abundance of PtdIns4P. Participates in a variety of cellular processes such as vesicle mediated transport, cell adhesion, cell polarization and cell migration. Together with PIP5K1A is required for phagocytosis, but they regulate different types of actin remodeling at sequential steps. Promotes particle attachment by generating the pool of PtdIns(4,5)P2 that induces controlled actin depolymerization to facilitate Fc-gamma-R clustering. Mediates RAC1-dependent reorganization of actin filaments. Required for synaptic vesicle transport. Controls the plasma membrane pool of PtdIns(4,5)P2 implicated in synaptic vesicle endocytosis and exocytosis. Plays a role in endocytosis mediated by clathrin and AP-2 (adaptor protein complex 2). Required for clathrin-coated pits assembly at the synapse. Participates in cell junction assembly. Modulates adherens junctions formation by facilitating CDH1 trafficking. Required for focal adhesion dynamics. Modulates the targeting of talins (TLN1 and TLN2) to the plasma membrane and their efficient assembly into focal adhesions. Regulates the interaction between talins (TLN1 and TLN2) and beta-integrins. Required for uropodium formation and retraction of the cell rear during directed migration. Has a role in growth factor- stimulated directional cell migration and adhesion. Required for talin assembly into nascent adhesions forming at the leading edge toward the direction of the growth factor. Negative regulator of T-cell activation and adhesion. Negatively regulates integrin alpha-L/beta-2 (LFA-1) polarization and adhesion induced by T-cell receptor. Together with PIP5K1A has a role during embryogenesis and together with PIP5K1B may have a role immediately after birth.
Gene: PIP5K1C
- 分子量
- 80 kDa
- 基因ID
- 23396
- UniProt
- O60331
- 途径
- PI3K-Akt Signaling, Inositol Metabolic Process, Cell-Cell Junction Organization, Maintenance of Protein Location, Synaptic Vesicle Exocytosis
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