GPR161 抗体 (Internal Region)
-
- 抗原 See all GPR161 抗体
- GPR161 (G Protein-Coupled Receptor 161 (GPR161))
-
抗原表位
- Internal Region
-
适用
- 人
-
宿主
- 兔
-
克隆类型
- 多克隆
-
标记
- This GPR161 antibody is un-conjugated
-
应用范围
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
- 特异性
- GPR161 Antibody detects endogenous levels of total GPR161.
- 预测反应
- Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken
- 纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- 免疫原
- A synthesized peptide derived from human GPR161, corresponding to a region within the internal amino acids.
- 亚型
- IgG
- Top Product
- Discover our top product GPR161 Primary Antibody
-
-
- 应用备注
- WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
- 限制
- 仅限研究用
-
- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 有效期
- 12 months
-
- 抗原
- GPR161 (G Protein-Coupled Receptor 161 (GPR161))
- 别名
- GPR161 (GPR161 产品)
- 别名
- RE2 antibody, Gm208 antibody, Gm208Gpr antibody, vl antibody, RGD1563245 antibody, si:bz20i5.4 antibody, si:rp71-20i5.4 antibody, G protein-coupled receptor 161 antibody, GPR161 antibody, Gpr161 antibody, gpr161 antibody
- 背景
-
Description: Key negative regulator of Shh signaling, which promotes the processing of GLI3 into GLI3R during neural tube development. Recruited by TULP3 and the IFT-A complex to primary cilia and acts as a regulator of the PKA-dependent basal repression machinery in Shh signaling by increasing cAMP levels, leading to promote the PKA-dependent processing of GLI3 into GLI3R and repress the Shh signaling. In presence of SHH, it is removed from primary cilia and is internalized into recycling endosomes, preventing its activity and allowing activation of the Shh signaling. Its ligand is unknown (By similarity).
Gene: GPR161
- 分子量
- 65 kDa
- 基因ID
- 23432
- UniProt
- Q8N6U8
- 途径
- cAMP Metabolic Process
-