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- 抗原 See all E2F7 抗体
- E2F7 (E2F Transcription Factor 7 (E2F7))
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This E2F7 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
- 特异性
- E2F7 antibody detects endogenous levels of total E2F7
- 交叉反应
- 人
- 纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- 免疫原
- A synthesized peptide
- 亚型
- IgG
- Top Product
- Discover our top product E2F7 Primary Antibody
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anti-E2F Transcription Factor 7 (E2F7) (N-Term) antibody
E2F7 适用: 人, 小鼠, 犬, 大鼠, Cow, 兔, 马, Pig WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-E2F Transcription Factor 7 (E2F7) antibodyE2F7 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-E2F Transcription Factor 7 (E2F7) (AA 540-740) antibodyE2F7 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-E2F Transcription Factor 7 (E2F7) (AA 108-157) antibodyE2F7 适用: 小鼠, 大鼠, 豚鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-E2F Transcription Factor 7 (E2F7) (Internal Region) antibodyVerified E2F7 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
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- 应用备注
- WB 1:500-1:2000 IHC 1:50-1:200
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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- 抗原
- E2F7 (E2F Transcription Factor 7 (E2F7))
- 别名
- E2F7 (E2F7 产品)
- 别名
- E2F7 antibody, E2F-7 antibody, fc43h03 antibody, si:dkey-217k21.2 antibody, wu:fc43h03 antibody, MGC154335 antibody, A630014C11Rik antibody, D10Ertd739e antibody, E2F transcription factor 7 antibody, E2F transcription factor 7 L homeolog antibody, E2F7 antibody, e2f7 antibody, e2f7.L antibody, E2f7 antibody
- 背景
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Description: Atypical E2F transcription factor that participates in various processes such as angiogenesis, polyploidization of specialized cells and DNA damage response. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'-TTTC[CG]CGC-3'. Directly represses transcription of classical E2F transcription factors such as E2F1. Acts as a regulator of S-phase by recognizing and binding the E2-related site 5'-TTCCCGCC-3' and mediating repression of G1/S-regulated genes. Plays a key role in polyploidization of cells in placenta and liver by regulating the endocycle, probably by repressing genes promoting cytokinesis and antagonizing action of classical E2F proteins (E2F1, E2F2 and/or E2F3). Required for placental development by promoting polyploidization of trophoblast giant cells. Also involved in DNA damage response: up-regulated by p53/TP53 following genotoxic stress and acts as a downstream effector of p53/TP53-dependent repression by mediating repression of indirect p53/TP53 target genes involved in DNA replication. Acts as a promoter of sprouting angiogenesis, possibly by acting as a transcription activator: associates with HIF1A, recognizes and binds the VEGFA promoter, which is different from canonical E2 recognition site, and activates expression of the VEGFA gene. Acts as a negative regulator of keratinocyte differentiation.
Gene: E2F7
- 分子量
- 99 kDa
- 基因ID
- 144455
- UniProt
- Q96AV8
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