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PKC zeta 抗体 (pThr560)

Name: PKC zeta 抗体 (pThr560)
SKU: ABIN6256579
Availability: OutOfStock

This anti-PKC zeta antibody is a 兔多克隆 antibody detecting PKC zeta in WB, ELISA, IHC, IF 和 ICC. Suitable for 人, 小鼠和大鼠.

Western blot analysis of PKC zeta phosphorylation expression in PMA treated COS7 whole cell lysates,The lane on the left is treated with the antigen-specific peptide. (PKC zeta 抗体 (pThr560))

IF/ICC

ABIN6267614 at 1/100 staining Mouse testis tissue by IHC-P. (PKC zeta 抗体 (pThr560))

IHC

3 images

产品编号 ABIN6256579

发货至: 中国

Quick Overview for PKC zeta 抗体 (pThr560) (ABIN6256579)

抗原

See all PKC zeta (PRKCZ) 抗体

PKC zeta (PRKCZ) (Protein Kinase C, zeta (PRKCZ))

适用

人, 小鼠, 大鼠

宿主

兔

克隆类型

多克隆

标记

This PKC zeta antibody is un-conjugated

应用范围

Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Discover our top product PRKCZ Primary Antibody

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pThr560

特异性

Phospho-PKC zeta (Thr560) Antibody detects endogenous levels of PKC zeta only when phosphorylated at Threonine 560

交叉反应

人, 小鼠, 大鼠

纯化方法

The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.

免疫原

A synthesized peptide derived from human PKC zeta around the phosphorylation site of Threonine 560

亚型

IgG
anti-Protein Kinase C, zeta (PRKCZ) (C-Term) antibody
PRKCZ 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Protein Kinase C, zeta (PRKCZ) (pThr410) antibody
PRKCZ 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Protein Kinase C, zeta (PRKCZ) (AA 165-255) antibody
PRKCZ 适用: 人 WB, ELISA, RNAi 宿主: 小鼠 Monoclonal 2D1 unconjugated

anti-Protein Kinase C, zeta (PRKCZ) (AA 453-592) antibody
PRKCZ 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated

anti-Protein Kinase C, zeta (PRKCZ) (Cytoplasmic Domain) antibody
PRKCZ 适用: 人 ELISA, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Protein Kinase C, zeta (PRKCZ) antibody
PRKCZ 适用: 人, 小鼠, 大鼠 WB, ELISA, IP 宿主: 兔 Monoclonal R14-K unconjugated

anti-Protein Kinase C, zeta (PRKCZ) (N-Term) antibody
PRKCZ 适用: 人 ELISA, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Protein Kinase C, zeta (PRKCZ) (Thr33) antibody
PRKCZ 适用: 人, 小鼠, 大鼠, 猴 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Protein Kinase C, zeta (PRKCZ) (pThr410) antibody
PRKCZ 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Protein Kinase C, zeta (PRKCZ) (AA 1-592) antibody
PRKCZ 适用: 人 WB, PLA 宿主: 兔 Polyclonal unconjugated

应用备注

WB 1:500-1:2000 IHC 1:50-1:200, IF/ICC 1:100-1:500

限制

仅限研究用
状态

Liquid

浓度

1 mg/mL

缓冲液

Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

-20 °C

储存方法

Store at -20 °C.Stable for 12 months from date of receipt

有效期

12 months
抗原

PKC zeta (PRKCZ) (Protein Kinase C, zeta (PRKCZ))

别名

PKC zeta

背景

Description: Calcium- and diacylglycerol-independent serine/threonine-protein kinase that functions in phosphatidylinositol 3-kinase (PI3K) pathway and mitogen-activated protein (MAP) kinase cascade, and is involved in NF-kappa-B activation, mitogenic signaling, cell proliferation, cell polarity, inflammatory response and maintenance of long-term potentiation (LTP). Upon lipopolysaccharide (LPS) treatment in macrophages, or following mitogenic stimuli, functions downstream of PI3K to activate MAP2K1/MEK1-MAPK1/ERK2 signaling cascade independently of RAF1 activation. Required for insulin-dependent activation of AKT3, but may function as an adapter rather than a direct activator. Upon insulin treatment may act as a downstream effector of PI3K and contribute to the activation of translocation of the glucose transporter SLC2A4/GLUT4 and subsequent glucose transport in adipocytes. In EGF-induced cells, binds and activates MAP2K5/MEK5-MAPK7/ERK5 independently of its kinase activity and can activate JUN promoter through MEF2C. Through binding with SQSTM1/p62, functions in interleukin-1 signaling and activation of NF-kappa-B with the specific adapters RIPK1 and TRAF6. Participates in TNF-dependent transactivation of NF-kappa-B by phosphorylating and activating IKBKB kinase, which in turn leads to the degradation of NF-kappa-B inhibitors. In migrating astrocytes, forms a cytoplasmic complex with PARD6A and is recruited by CDC42 to function in the establishment of cell polarity along with the microtubule motor and dynein. In association with FEZ1, stimulates neuronal differentiation in PC12 cells. In the inflammatory response, is required for the T-helper 2 (Th2) differentiation process, including interleukin production, efficient activation of JAK1 and the subsequent phosphorylation and nuclear translocation of STAT6. May be involved in development of allergic airway inflammation (asthma), a process dependent on Th2 immune response. In the NF-kappa-B-mediated inflammatory response, can relieve SETD6-dependent repression of NF-kappa-B target genes by phosphorylating the RELA subunit at 'Ser-311'. Necessary and sufficient for LTP maintenance in hippocampal CA1 pyramidal cells. In vein endothelial cells treated with the oxidant peroxynitrite, phosphorylates STK11 leading to nuclear export of STK11, subsequent inhibition of PI3K/Akt signaling, and increased apoptosis. Phosphorylates VAMP2 in vitro (PubMed:17313651).
Gene: PRKCZ

分子量

80kDa

基因ID

5590

UniProt

Q05513

途径

NF-kappaB Signaling, RTK signaling, Myometrial Relaxation and Contraction, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Synaptic Membrane, Production of Molecular Mediator of Immune Response, CXCR4-mediated Signaling Events, Thromboxane A2 Receptor Signaling