TLK1 抗体 (pSer743)
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北京 101111
Quick Overview for TLK1 抗体 (pSer743) (ABIN6256417)
抗原
See all TLK1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- pSer743
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特异性
- Phospho-TLK1 (Ser743) Antibody detects endogenous levels of TLK1.
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交叉反应
- 人, 小鼠
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纯化方法
- The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
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免疫原
- A synthesized peptide derived from human TLK1 around the phosphorylation site of Ser743.
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亚型
- IgG
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应用备注
- WB 1:500-1:2000, IHC 1:50-1:200
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20 °C.Stable for 12 months from date of receipt
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有效期
- 12 months
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- TLK1 (Tousled-Like Kinase 1 (TLK1))
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别名
- TLK1
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背景
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Description: Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10'.
Gene: TLK1
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分子量
- 86kDa
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基因ID
- 9874
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UniProt
- Q9UKI8
抗原
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