EPHA2/3/4 抗体 (pTyr588, pTyr596)
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- 抗原 See all EPHA2/3/4 products
- EPHA2/3/4 (EPH Receptor A2/3/4 (EPHA2/3/4))
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抗原表位
- pTyr588, pTyr596
- 适用
- 人, 大鼠, 小鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This EPHA2/3/4 antibody is un-conjugated
- 应用范围
- Western Blotting (WB), Immunofluorescence (IF), ELISA, Immunocytochemistry (ICC)
- 特异性
- Phospho-EPHA2/3/4(Tyr588/596) Antibody detects endogenous levels of EPHA2 and 3 only when phosphorylated at Tyrosine 588 and 596
- 交叉反应
- 人, 小鼠, 大鼠
- 纯化方法
- The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
- 免疫原
- A synthesized peptide derived from human EPHA2/3/4 around the phosphorylation site of Tyrosine 588 and 596
- 亚型
- IgG
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anti-EPH Receptor A2/3/4 (EPHA2/3/4) antibody
EPHA2/3/4 适用: 人, 大鼠 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-EPH Receptor A2/3/4 (EPHA2/3/4) (Lys14) antibodyEPHA2/3/4 适用: 人, 大鼠 WB, IF, ELISA 宿主: 兔 Polyclonal unconjugated
anti-EPH Receptor A2/3/4 (EPHA2/3/4) (pTyr588), (pTyr596) antibodyEPHA2/3/4 适用: 人, 大鼠, 小鼠 WB, IF, ELISA 宿主: 兔 Polyclonal unconjugated
anti-EPH Receptor A2/3/4 (EPHA2/3/4) (Tyr588), (Tyr596) antibodyEPHA2/3/4 适用: 人, 大鼠 WB, ELISA, IF/ICC 宿主: 兔 Polyclonal unconjugated
anti-EPH Receptor A2/3/4 (EPHA2/3/4) (AA 556-605) antibodyEPHA2/3/4 适用: 人, 大鼠 WB, IF, ELISA 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB 1:500-1:2000 IF/ICC 1:100-1:500
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20 °C.Stable for 12 months from date of receipt
- 有效期
- 12 months
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- 抗原
- EPHA2/3/4 (EPH Receptor A2/3/4 (EPHA2/3/4))
- 别名
- EPHA2/3/4 (EPHA2/3/4 产品)
- 背景
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Description: Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway. May also participate in UV radiation-induced apoptosis and have a ligand-independent stimulatory effect on chemotactic cell migration. During development, may function in distinctive aspects of pattern formation and subsequently in development of several fetal tissues. Involved for instance in angiogenesis, in early hindbrain development and epithelial proliferation and branching morphogenesis during mammary gland development. Engaged by the ligand ephrin-A5/EFNA5 may regulate lens fiber cells shape and interactions and be important for lens transparency development and maintenance. With ephrin-A2/EFNA2 may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis.
Gene: EPHA2
- 分子量
- 130kDa
- 基因ID
- 1969
- UniProt
- P29317, P29320, P54764
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