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- 抗原 See all PAXIP1 抗体
- PAXIP1 (PAX Interacting (With Transcription-Activation Domain) Protein 1 (PAXIP1))
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抗原表位
- AA 2-35, N-Term
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This PAXIP1 antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 纯化方法
- This antibody is purified through a protein A column, followed by peptide affinity purification.
- 免疫原
- This PAXIP1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 2-35 amino acids from the N-terminal region of human PAXIP1.
- 克隆位点
- RB47860
- 亚型
- Ig Fraction
- Top Product
- Discover our top product PAXIP1 Primary Antibody
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anti-PAX Interacting (With Transcription-Activation Domain) Protein 1 (PAXIP1) (AA 868-975) antibody
PAXIP1 适用: 人 ELISA, WB, IF 宿主: 小鼠 Monoclonal 4C11 unconjugated
anti-PAX Interacting (With Transcription-Activation Domain) Protein 1 (PAXIP1) (AA 613-812) antibodyPAXIP1 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-PAX Interacting (With Transcription-Activation Domain) Protein 1 (PAXIP1) (AA 1-757) antibodyPAXIP1 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-PAX Interacting (With Transcription-Activation Domain) Protein 1 (PAXIP1) (AA 868-975) antibodyPAXIP1 适用: 人 ELISA, WB 宿主: 小鼠 Polyclonal unconjugated
anti-PAX Interacting (With Transcription-Activation Domain) Protein 1 (PAXIP1) (AA 248-297) antibodyPAXIP1 适用: 人, 小鼠, 大鼠, Cow, 犬, 斑马鱼, 豚鼠, 马, 兔, 非洲爪蟾, 小鸡, 猴 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB: 1:1000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 有效期
- 6 months
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- 抗原
- PAXIP1 (PAX Interacting (With Transcription-Activation Domain) Protein 1 (PAXIP1))
- 别名
- PAXIP1 (PAXIP1 产品)
- 别名
- CAGF29 antibody, PACIP1 antibody, PAXIP1L antibody, PTIP antibody, TNRC2 antibody, wu:fa04b06 antibody, zgc:92593 antibody, cagf28 antibody, cagf29 antibody, k14 antibody, pacip1 antibody, paxip1l antibody, ptip antibody, tnrc2 antibody, D5Ertd149e antibody, PAX interacting protein 1 antibody, PAX interacting (with transcription-activation domain) protein 1 antibody, PAX interacting protein 1 L homeolog antibody, PAXIP1 antibody, paxip1 antibody, paxip1.L antibody, Paxip1 antibody
- 背景
- Involved in DNA damage response and in transcriptional regulation through histone methyltransferase (HMT) complexes. Plays a role in early development. In DNA damage response is required for cell survival after ionizing radiation. In vitro shown to be involved in the homologous recombination mechanism for the repair of double-strand breaks (DSBs). Its localization to DNA damage foci requires RNF8 and UBE2N. Recruits TP53BP1 to DNA damage foci and, at least in particular repair processes, effective DNA damage response appears to require the association with TP53BP1 phosphorylated by ATM at 'Ser-25'. Together with TP53BP1 regulates ATM association. Recruits PAGR1 to sites of DNA damage and the PAGR1:PAXIP1 complex is required for cell survival in response to DNA damage, the function is probbaly independent of MLL-containing histone methyltransferase (HMT) complexes. Promotes ubiquitination of PCNA following UV irradiation and may regulate recruitment of polymerase eta and RAD51 to chromatin after DNA damage. Proposed to be involved in transcriptional regulation by linking MLL-containing histone methyltransferase (HMT) complexes to gene promoters by interacting with promoter-bound transcription factors such as PAX2. Associates with gene promoters that are known to be regulated by KMT2D/MLL2. During immunoglobulin class switching in activated B-cells is involved in trimethylation of histone H3 at 'Lys-4' and in transcription initiation of downstream switch regions at the immunoglobulin heavy-chain (Igh) locus, this function appears to involve the recruitment of MLL- containing HMT complexes.
- 分子量
- 121341
- UniProt
- Q6ZW49
- 途径
- Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response
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