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- 抗原 See all RBCK1 抗体
- RBCK1 (RanBP-Type and C3HC4-Type Zinc Finger Containing 1 (RBCK1))
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This RBCK1 antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 纯化方法
- This antibody is purified through a protein G column, followed by dialysis against PBS.
- 免疫原
- This RBCK1 (UBCE7IP3) antibody is generated from a mouse immunized with a recombinant protein of human RBCK1 (UBCE7IP3).
- 克隆位点
- 1839CT718-19-54
- 亚型
- IgG1 kappa
- Top Product
- Discover our top product RBCK1 Primary Antibody
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anti-RanBP-Type and C3HC4-Type Zinc Finger Containing 1 (RBCK1) (AA 3-99) antibody
RBCK1 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 3C3 unconjugated
anti-RanBP-Type and C3HC4-Type Zinc Finger Containing 1 (RBCK1) antibodyRBCK1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-RanBP-Type and C3HC4-Type Zinc Finger Containing 1 (RBCK1) (AA 1-230) antibodyRBCK1 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-RanBP-Type and C3HC4-Type Zinc Finger Containing 1 (RBCK1) (N-Term) antibodyRBCK1 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-RanBP-Type and C3HC4-Type Zinc Finger Containing 1 (RBCK1) antibodyRBCK1 适用: 人 WB, IHC (p) 宿主: 小鼠 Monoclonal CL4289 unconjugated
anti-RanBP-Type and C3HC4-Type Zinc Finger Containing 1 (RBCK1) (AA 251-350) antibodyRBCK1 适用: 小鼠 WB, ELISA, IF (cc), IF (p), IHC (p), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-RanBP-Type and C3HC4-Type Zinc Finger Containing 1 (RBCK1) (AA 162-261) antibodyRBCK1 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-RanBP-Type and C3HC4-Type Zinc Finger Containing 1 (RBCK1) (AA 1-230) antibodyRBCK1 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-RanBP-Type and C3HC4-Type Zinc Finger Containing 1 (RBCK1) (AA 181-230) antibodyRBCK1 适用: 人, 小鼠, Cow, 豚鼠, Bat WB 宿主: 兔 Polyclonal unconjugated
anti-RanBP-Type and C3HC4-Type Zinc Finger Containing 1 (RBCK1) (AA 1-30), (N-Term) antibodyRBCK1 适用: 人 WB 宿主: 兔 Polyclonal RB42651 unconjugated
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- 应用备注
- WB: 1:2000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 有效期
- 6 months
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- 抗原
- RBCK1 (RanBP-Type and C3HC4-Type Zinc Finger Containing 1 (RBCK1))
- 别名
- RBCK1 (UBCE7IP3) (RBCK1 产品)
- 别名
- RBCK1 antibody, C20orf18 antibody, HOIL-1 antibody, HOIL1 antibody, RBCK2 antibody, RNF54 antibody, UBCE7IP3 antibody, XAP3 antibody, XAP4 antibody, ZRANB4 antibody, C20ORF18 antibody, AL033326 antibody, HOIL-1L antibody, UIP28 antibody, Ubce7ip3 antibody, Pkcbpb15 antibody, zgc:91964 antibody, SHANK-associated RH domain interactor antibody, RANBP2-type and C3HC4-type zinc finger containing 1 antibody, ranBP-type and C3HC4-type zinc finger-containing protein 1 antibody, RanBP-type and C3HC4-type zinc finger containing 1 antibody, SHARPIN antibody, RBCK1 antibody, LOC100411512 antibody, Rbck1 antibody, rbck1 antibody
- 背景
- E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, such as UBE2L3/UBCM4, and then transfers it to substrates. Functions as an E3 ligase for oxidized IREB2 and both heme and oxygen are necessary for IREB2 ubiquitination. Promotes ubiquitination of TAB2 and IRF3 and their degradation by the proteasome. Component of the LUBAC complex which conjugates linear ('Met-1'-linked) polyubiquitin chains to substrates and plays a key role in NF- kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF- RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Together with FAM105B/otulin, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis. Binds polyubiquitin of different linkage types.
- 分子量
- 57572
- UniProt
- Q9BYM8
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