MAP2K7 抗体 (AA 363-396)
Quick Overview for MAP2K7 抗体 (AA 363-396) (ABIN6243258)
抗原
See all MAP2K7 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
-
-
抗原表位
- AA 363-396
-
纯化方法
- This antibody is purified through a protein A column, followed by peptide affinity purification.
-
免疫原
- This MAP2K7 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 363-396 amino acids of human MAP2K7.
-
亚型
- Ig Fraction
-
-
anti-Mitogen-Activated Protein Kinase Kinase 7 (MAP2K7) antibody
MAP2K7 适用: 人 ELISA, IHC, ICC, FACS 宿主: 小鼠 Monoclonal 4E5 unconjugated
anti-Mitogen-Activated Protein Kinase Kinase 7 (MAP2K7) (AA 1-250) antibodyMAP2K7 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase Kinase 7 (MAP2K7) (AA 1-99) antibodyMAP2K7 适用: 人 WB, ELISA, IF, IHC (p), PLA 宿主: 小鼠 Monoclonal 2G5 unconjugated
anti-Mitogen-Activated Protein Kinase Kinase 7 (MAP2K7) (AA 113-388) antibodyMAP2K7 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase Kinase 7 (MAP2K7) (AA 2-40), (N-Term) antibodyMAP2K7 适用: 人, 小鼠, 大鼠, 猴 WB, IHC, IF, ICC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase Kinase 7 (MAP2K7) (AA 17-160) antibodyMAP2K7 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase Kinase 7 (MAP2K7) (Internal Region) antibodyMAP2K7 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase Kinase 7 (MAP2K7) antibodyMAP2K7 适用: 人 WB 宿主: 兔 Monoclonal unconjugated
anti-Mitogen-Activated Protein Kinase Kinase 7 (MAP2K7) (AA 206-233) antibodyMAP2K7 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase Kinase 7 (MAP2K7) (pSer271), (pThr275) antibodyMAP2K7 适用: 人, 小鼠, 大鼠 WB, ELISA, IF (cc), IF (p), FACS, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
- WB: 1:2000
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- 4 °C,-20 °C
-
有效期
- 6 months
-
-
- MAP2K7 (Mitogen-Activated Protein Kinase Kinase 7 (MAP2K7))
-
别名
- MAP2K7
-
背景
- Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K4/MKK4, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4/MKK4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The monophosphorylation of JNKs on the Thr residue is sufficient to increase JNK activity indicating that MAP2K7/MKK7 is important to trigger JNK activity, while the additional phosphorylation of the Tyr residue by MAP2K4/MKK4 ensures optimal JNK activation. Has a specific role in JNK signal transduction pathway activated by proinflammatory cytokines. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis.
-
分子量
- 47485
-
UniProt
- O14733
-
途径
- MAPK Pathway, TLR signaling, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades, BCR Signaling
抗原
-
