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APOBEC3C 抗体 (AA 143-177)

APOBEC3C 适用: 人 WB 宿主: 兔 Polyclonal RB56223 unconjugated
产品编号 ABIN6243035
发货至: 中国
  • 抗原 See all APOBEC3C 抗体
    APOBEC3C (Apolipoprotein B mRNA Editing Enzyme, Catalytic Polypeptide-Like 3C (APOBEC3C))
    抗原表位
    • 15
    • 6
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 143-177
    适用
    • 31
    • 2
    • 1
    • 1
    宿主
    • 26
    • 4
    • 1
    克隆类型
    • 29
    • 2
    多克隆
    标记
    • 17
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This APOBEC3C antibody is un-conjugated
    应用范围
    • 27
    • 13
    • 13
    • 10
    • 4
    • 4
    • 3
    • 3
    • 3
    • 1
    • 1
    Western Blotting (WB)
    纯化方法
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    免疫原
    This APOBEC3C antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 143-177 amino acids from human APOBEC3C.
    克隆位点
    RB56223
    亚型
    Ig Fraction
    Top Product
    Discover our top product APOBEC3C Primary Antibody
  • 应用备注
    WB: 1:2000
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    有效期
    6 months
  • 抗原
    APOBEC3C (Apolipoprotein B mRNA Editing Enzyme, Catalytic Polypeptide-Like 3C (APOBEC3C))
    别名
    APOBEC3C (APOBEC3C 产品)
    别名
    APOBEC3C antibody, A3C antibody, APOBEC1L antibody, ARDC2 antibody, ARDC4 antibody, ARP5 antibody, PBI antibody, bK150C2.3 antibody, apolipoprotein B mRNA editing enzyme catalytic subunit 3C antibody, apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C antibody, APOBEC3C antibody
    背景
    DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination- independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single-or double- stranded RNA. Exhibits antiviral activity against simian immunodeficiency virus (SIV), hepatitis B virus (HBV), herpes simplex virus 1 (HHV-1) and Epstein-Barr virus (EBV) and may inhibit the mobility of LTR and non-LTR retrotransposons. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation.
    分子量
    22826
    UniProt
    Q9NRW3
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