This antibody is purified through a protein A column, followed by peptide affinity purification.
免疫原
This SMARCD3 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 27-60 amino acids from the N-terminal region of human SMARCD3.
SMARCD3 antibody, baf60c antibody, cracd3 antibody, rsc6p antibody, BAF60C antibody, CRACD3 antibody, Rsc6p antibody, 1500001J14Rik antibody, 2210409C08Rik antibody, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 antibody, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 S homeolog antibody, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3b antibody, SMARCD3 antibody, smarcd3.S antibody, Smarcd3 antibody, smarcd3b antibody
背景
Plays a role in ATP dependent nucleosome remodeling by SMARCA4 containing complexes. Stimulates nuclear receptor mediated transcription. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron- specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post- mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity).