Desmoglein 1 抗体
-
- 抗原 See all Desmoglein 1 (DSG1) 抗体
- Desmoglein 1 (DSG1)
-
适用
- 人
-
宿主
- 小鼠
-
克隆类型
- 单克隆
-
标记
- This Desmoglein 1 antibody is un-conjugated
-
应用范围
- Immunofluorescence (IF), Immunohistochemistry (IHC), Flow Cytometry (FACS)
- 原理
- Mouse Monoclonal anti-Desmoglein-1 (DSG1/1733), Purified, BSA-free
- 产品特性
- This antibody recognizes a protein of ~150 kDa, identified as Desmoglein-1 (DSG1). Desmoglein-1 is a member of the desmosomal cadherin family. Desmosomes are intercellular adhering junctions that represent cell surface attachment sites for intermediate filament. Desmocollins and desmogleins are the main desmosomal transmembrane proteins. Desmogleins consist of Dsg1, Dsg2, Dsg3, and Dsg4 isoforms. Within the desmosome, the extracellular domain of desmoglein is essential for calcium dependent heterophilic binding to the desmocollins, whereas the intracellular domain is essential for binding to the desmosomal plaque protein, plakoglobin. Desmoglein 1 is synthesized exclusively in the suprabasal layers. Intact and functionally active desmoglein 1 is essential to epidermal integrity. Primary antibodies are available purified, or with a selection of fluorescent CF® dyes and other labels. CF® dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
- 纯化方法
- Purified
- 免疫原
- Recombinant human desmoglein-1 protein fragment corresponding to intracellular domain (exact sequence is proprietary)
- 克隆位点
- DSG1-1733
- 亚型
- IgG1 kappa
- Top Product
- Discover our top product DSG1 Primary Antibody
-
anti-Desmoglein 1 (DSG1) (AA 30-90) antibody
DSG1 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Desmoglein 1 (DSG1) antibodyDSG1 适用: 人 IHC, StM 宿主: 小鼠 Monoclonal 32-2B unconjugated
anti-Desmoglein 1 (DSG1) antibodyDSG1 适用: 人 IHC 宿主: 小鼠 Monoclonal MSVA-544M unconjugated
anti-Desmoglein 1 (DSG1) (AA 384-539) antibodyDSG1 适用: 人 IF, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Desmoglein 1 (DSG1) (N-Term) antibodyDSG1 适用: 人, 小鼠, 大鼠 WB, IF, ELISA, ICC 宿主: 兔 Polyclonal unconjugated
anti-Desmoglein 1 (DSG1) (AA 1-1049) antibodyDSG1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Desmoglein 1 (DSG1) (AA 1-1049) antibodyDSG1 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Desmoglein 1 (DSG1) (AA 800-1049) antibodyDSG1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Desmoglein 1 (DSG1) (AA 710-961) antibodyDSG1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Desmoglein 1 (DSG1) antibodyDSG1 适用: 人, 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
-
- 应用备注
-
Immunohistology (formalin) 0.5-1 μg/mL
- Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM Tris buffer with 1 mM EDTA pH 8.0 for 10-20 min followed by cooling at RT for 20 min
- Flow Cytometry 0.5-1 μg/million cells/0.1 mL
- Immunofluorescence 1-2 μg/mL
- Optimal dilution for a specific application should be determined by user
- 说明
-
A431 or A-375 cells. Skin
- 限制
- 仅限研究用
-
- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- PBS (no BSA, no azide)
- 储存液
- Azide free
-
- 抗原
- Desmoglein 1 (DSG1)
- 别名
- Desmoglein-1 (DSG1 产品)
- 别名
- CDHF4 antibody, DG1 antibody, DSG antibody, PPKS1 antibody, SPPK1 antibody, DSG-1 antibody, DSG1 antibody, Dsg1b antibody, Dsg1c antibody, desmoglein 1 antibody, desmoglein 4 antibody, DSG1 antibody, DSG4 antibody, Dsg1 antibody
- 背景
- Cadherin family member 4, CDHF4, Desmoglein-1, Desmosomal glycoprotein 1, DG1, DSG1, EPKHE, EPKHIA, Pemphigus foliaceus antigen, PPKS1, SPPK1
- 分子量
- 150 kDa (precursor), 160 kDa (mature)
- 基因ID
- 1828, 2633
- UniProt
- Q02413
- 途径
- Cell-Cell Junction Organization
-
