TSHR, B Chain 抗体
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- 抗原 See all TSHR, B Chain products
- TSHR, B Chain (Thyroid Stimulating Hormone Receptor, B Chain (TSHR, B Chain))
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This TSHR, B Chain antibody is un-conjugated
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应用范围
- Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (IHC)
- 原理
- Mouse Monoclonal anti-TSH Receptor, B chain (TSHRB/1405), Purified, BSA-free
- 产品特性
- Thyroid-stimulating hormone (TSH, also known as thyrotropin) is a glycoprotein involved in the control of thyroid structure and metabolism, which stimulates the release of the thyroid hormones. TSH is regulated by thyroid hormone (T3) and various retinoid compounds. TSH binds to the thyroid-stimulating hormone receptor (TSHR), which is cleaved into two subunits, A and B, and plays a major role in regulating thyroid function. The third cytoplasmic loop of TSHR has been identified as critical for its role in regulating inositol phosphate and cAMP formation. In Grave s disease, an autoimmune disorder, TSHR is activated by autoantibodies, which may be stimulated by the cleavage of the A and B subunits. Primary antibodies are available purified, or with a selection of fluorescent CF® dyes and other labels. CF® dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
- 纯化方法
- Purified
- 免疫原
- B-Chain protein|Recombinant human TSHR
- 克隆位点
- TSHRB-1405
- 亚型
- IgG2a
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anti-Thyroid Stimulating Hormone Receptor, B Chain (TSHR, B Chain) antibody
TSHR, B Chain 适用: 人 FACS, IF, IHC (p) 宿主: 小鼠 Monoclonal SPM222 unconjugated
anti-Thyroid Stimulating Hormone Receptor, B Chain (TSHR, B Chain) antibodyTSHR, B Chain 适用: 人 FACS, IF, IHC (p) 宿主: 小鼠 Monoclonal SPM222 unconjugated
anti-Thyroid Stimulating Hormone Receptor, B Chain (TSHR, B Chain) (AA 515-538) antibodyTSHR, B Chain 适用: 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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Immunohistology (formalin) 1-2 μg/mL
- Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM Tris buffer with 1 mM EDTA pH 8.0 for 10-20 min followed by cooling at RT for 20 min
- Flow Cytometry 0.5-1 μg/million cells/0.1 mL
- Immunofluorescence 1-2 μg/mL
- Optimal dilution for a specific application should be determined by user
- 说明
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293T Cells. Thyroid gland
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- PBS (no BSA, no azide)
- 储存液
- Azide free
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- 抗原
- TSHR, B Chain (Thyroid Stimulating Hormone Receptor, B Chain (TSHR, B Chain))
- 别名
- TSH Receptor, B chain (TSHR, B Chain 产品)
- 背景
- CHNG1, hTSHRI, LGR3, Thyroid-stimulating hormone receptor, Thyrotropin receptor, Thyrotropin receptor I, TSHR
- 分子量
- 42 kDa
- 基因ID
- 7253, 160411
- UniProt
- P16473
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