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- 抗原 See all eIF4EBP2 (EIF4EBP2) 抗体
- eIF4EBP2 (EIF4EBP2) (Eukaryotic Translation Initiation Factor 4E Binding Protein 2 (EIF4EBP2))
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抗原表位
- AA 99-120
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This eIF4EBP2 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- 特异性
- Detects 17 and 20 kDa proteins, corresponding to the apparent molecular mass of PHAS-II and its phosphorylated state on SDS-PAGE immunoblots.
- 交叉反应 （详细）
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Species reactivity (expected):Bovine, Canine, Porcine, Mouse and Rat.
Species reactivity (tested):Human. - 纯化方法
- Immunoaffinity Chromatography
- 免疫原
- EIF4EBP2 antibody was raised against human PHAS-II synthetic peptide (residues 99-120) was synthesized and the peptide coupled to KLH. .Remarks: This sequence is 96% homologous to mouse PHAS-11 over these residues
- Top Product
- Discover our top product EIF4EBP2 Primary Antibody
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anti-Eukaryotic Translation Initiation Factor 4E Binding Protein 2 (EIF4EBP2) (AA 1-120) antibody
EIF4EBP2 适用: 人 ELISA, IHC, WB 宿主: 兔 Polyclonal unconjugated
anti-Eukaryotic Translation Initiation Factor 4E Binding Protein 2 (EIF4EBP2) antibodyEIF4EBP2 适用: 人, 小鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Eukaryotic Translation Initiation Factor 4E Binding Protein 2 (EIF4EBP2) (N-Term) antibodyEIF4EBP2 适用: 人, 小鼠, 大鼠, Cow, 犬, Pig, 山羊, 兔, 斑马鱼, 豚鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Eukaryotic Translation Initiation Factor 4E Binding Protein 2 (EIF4EBP2) (AA 1-120) antibodyEIF4EBP2 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Eukaryotic Translation Initiation Factor 4E Binding Protein 2 (EIF4EBP2) (AA 61-120) antibodyEIF4EBP2 适用: 人 ELISA, WB 宿主: 小鼠 Polyclonal unconjugated
anti-Eukaryotic Translation Initiation Factor 4E Binding Protein 2 (EIF4EBP2) (AA 61-120) antibodyEIF4EBP2 适用: 人 ELISA, WB 宿主: 小鼠 Monoclonal 2G8 unconjugated
anti-Eukaryotic Translation Initiation Factor 4E Binding Protein 2 (EIF4EBP2) (AA 7-56) antibodyEIF4EBP2 适用: 人, 小鼠, 大鼠, Cow, 犬, Pig, 山羊, 兔, 斑马鱼, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Eukaryotic Translation Initiation Factor 4E Binding Protein 2 (EIF4EBP2) (AA 87-115) antibodyEIF4EBP2 适用: 人 IHC, WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Eukaryotic Translation Initiation Factor 4E Binding Protein 2 (EIF4EBP2) (AA 87-115), (C-Term) antibodyEIF4EBP2 适用: 人 WB 宿主: 兔 Polyclonal RB41859 unconjugated
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 浓度
- 1,0 mg/mL
- 缓冲液
- BBS, pH 8.4 (25 mM sodium borate, 100 mM boric acid, 75 mM sodium chloride, 5 mM EDTA)
- 注意事项
- Avoid repeated freezing and thawing.
- 储存条件
- 4 °C/-20 °C
- 储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- 抗原
- eIF4EBP2 (EIF4EBP2) (Eukaryotic Translation Initiation Factor 4E Binding Protein 2 (EIF4EBP2))
- 别名
- 4E-BP2 (EIF4EBP2 产品)
- 别名
- 4ebp2 antibody, MGC75579 antibody, wu:fa55e11 antibody, wu:fp45e09 antibody, MGC78987 antibody, EIF4EBP2 antibody, eIF-4E antibody, Tb06.28P18.1010 antibody, 4EBP2 antibody, PHASII antibody, 2810011I19Rik antibody, 4E-BP2 antibody, AA792569 antibody, BC010348 antibody, PHAS-II antibody, eukaryotic translation initiation factor 4E binding protein 2 antibody, eukaryotic translation initiation factor 4E binding protein 2 L homeolog antibody, eukaryotic initiation factor 4E antibody, eukaryotic translation initiation factor 4E antibody, putative eukaryotic translation initiation factor 4e antibody, eif4ebp2 antibody, Eif4ebp2 antibody, eif4ebp2.L antibody, EIF4EBP2 antibody, eIF-4E antibody, Tb927.6.1870 antibody, LMJF_30_0450 antibody
- 背景
- PHAS-II, also known as eIF4E-binding protein II (eIF4E-BPII), is a member of a family of proteins which regulate initiation. PHAS-I and -II were found to have overlapping but different patterns of expression in tissues. PHAS-II shows the highest expression in liver and kidney where very little PHAS-I is found. The PHAS proteins regulate translation initiation by binding to the inhibitory protein eIF- 4E and blocking translation by preventing access of eIF-4G to the 5' cap of the mRNA. Both PHAS proteins are phosphorylated in response to insulin or growth factors such as EGF, PDGF and IGF-1. Phosphorylation in the appropriate site(s) promotes dissociation of PHAS/eIF-4E complexes which allows eIF-4E to bind eIF-4G(p220), thereby increasing the amount of eIF-4F complex and the rate of translation initiation. Regulation of the two protein differ because PHAS-II, unlike PHAS-I is readily phosphorylated by PKA in vitro. However increasing cAMP in cells promotes dephosphorylation of both PHAS-I and PHAS-II. Pharmacological and genetic evidence indicates that the mTOR/p70S6K pathway is involved in the control of PHAS-I and -II suggesting that these proteins may be mediators of the effects of this pathway on protein synthesis and cell proliferation.Synonyms: EIF4EBP2, Eukaryotic translation initiation factor 4E-binding protein 2, eIF4E-binding protein 2
- 基因ID
- 1979
- NCBI登录号
- NP_004087
- UniProt
- Q13542
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