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- 抗原 See all TRPM8 抗体
- TRPM8 (Transient Receptor Potential Cation Channel, Subfamily M, Member 8 (TRPM8))
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抗原表位
- AA 980-1104
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This TRPM8 antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 序列
- GYTVGTVQEN NDQVWKFQRY FLVQEYCSRL NIPFPFIVFA YFYMVVKKCF KCCCKEKNME SSVCCFKNED NETLAWEGVM KENYLVKINT KANDTSEEMR HRFRQLDTKL NDLKGLLKEI ANKIK
- 交叉反应
- 人
- 产品特性
- Polyclonal Antibodies
- 免疫原
- Recombinant fusion protein containing a sequence corresponding to amino acids 980-1104 of human TRPM8 (NP_076985.4).
- 亚型
- IgG
- Top Product
- Discover our top product TRPM8 Primary Antibody
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anti-Transient Receptor Potential Cation Channel, Subfamily M, Member 8 (TRPM8) (AA 926-956), (C-Term) antibody
TRPM8 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB14420 unconjugated
anti-Transient Receptor Potential Cation Channel, Subfamily M, Member 8 (TRPM8) (AA 521-552) antibodyTRPM8 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Transient Receptor Potential Cation Channel, Subfamily M, Member 8 (TRPM8) (AA 263-292) antibodyTRPM8 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Transient Receptor Potential Cation Channel, Subfamily M, Member 8 (TRPM8) (3rd Extracellular Loop), (AA 917-929) antibodyTRPM8 适用: 人, 大鼠, 小鼠 WB, IHC, IF, ICC, IP, LCI, Neut 宿主: 兔 Polyclonal unconjugated
anti-Transient Receptor Potential Cation Channel, Subfamily M, Member 8 (TRPM8) (AA 1-192) antibodyTRPM8 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Transient Receptor Potential Cation Channel, Subfamily M, Member 8 (TRPM8) (N-Term) antibodyTRPM8 适用: 人, 豚鼠, 犬, 兔, Bat, 猴, Hamster IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Transient Receptor Potential Cation Channel, Subfamily M, Member 8 (TRPM8) (AA 980-1104) antibodyTRPM8 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Transient Receptor Potential Cation Channel, Subfamily M, Member 8 (TRPM8) (Internal Region) antibodyTRPM8 适用: 人, 大鼠, 小鼠, 豚鼠, 猴 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Transient Receptor Potential Cation Channel, Subfamily M, Member 8 (TRPM8) (AA 251-300) antibodyTRPM8 适用: 人, 豚鼠, 犬, 兔, 马, Cow, Pig, Bat, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Transient Receptor Potential Cation Channel, Subfamily M, Member 8 (TRPM8) (AA 521-552) antibodyTRPM8 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB14417 unconjugated
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- 应用备注
- WB,1:500 - 1:2000
- 说明
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HIGH QUALITY
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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- 抗原
- TRPM8 (Transient Receptor Potential Cation Channel, Subfamily M, Member 8 (TRPM8))
- 别名
- TRPM8 (TRPM8 产品)
- 别名
- TRPM8 antibody, trpp8 antibody, ltrpc6 antibody, trpm8b antibody, LTRPC6 antibody, TRPP8 antibody, CMR1 antibody, LTrpC-6 antibody, Trp-p8 antibody, transient receptor potential cation channel subfamily M member 8 antibody, transient receptor potential cation channel subfamily M member 8b L homeolog antibody, transient receptor potential cation channel, subfamily M, member 8 antibody, TRPM8 antibody, trpm8b.L antibody, Trpm8 antibody
- 背景
- Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH . Involved in menthol sensation. Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. Activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. The chemical agonist menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing. In prostate cancer cells, shows strong inward rectification and high calcium selectivity in contrast to its behavior in normal cells which is characterized by outward rectification and poor cationic selectivity. Plays a role in prostate cancer cell migration. Isoform 2 and isoform 3 negatively regulate menthol- and cold-induced channel activity by stabilizing the closed state of the channel.,TRPM8,LTRPC6,TRPP8,Cancer,Signal Transduction,Endocrine & Metabolism,Neuroscience,TRPM8
- 分子量
- 5 kDa/18 kDa/79 kDa/127 kDa
- 基因ID
- 79054
- UniProt
- Q7Z2W7
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