-
- 抗原 See all GCN1L1 抗体
- GCN1L1 (GCN1 General Control of Amino-Acid Synthesis 1-Like 1 (Yeast) (GCN1L1))
-
抗原表位
- AA 2462-2671
-
适用
- 人
-
宿主
- 兔
-
克隆类型
- 多克隆
-
标记
- This GCN1L1 antibody is un-conjugated
-
应用范围
- Western Blotting (WB)
- 序列
- LSAVLQQCLL ADVSGIDWMV RHGRSLALSV AVNVAPGRLC AGRYSSDVQE MILSSATADR IPIAVSGVRG MGFLMRHHIE TGGGQLPAKL SSLFVKCLQN PSSDIRLVAE KMIWWANKDP LPPLDPQAIK PILKALLDNT KDKNTVVRAY SDQAIVNLLK MRQGEEVFQS LSKILDVASL EVLNEVNRRS LKKLASQADS TEQVDDTILT
- 交叉反应
- 人
- 产品特性
- Polyclonal Antibodies
- 纯化方法
- Affinity purification
- 免疫原
- Recombinant fusion protein containing a sequence corresponding to amino acids 2462-2671 of human GCN1L1 (NP_006827.1).
- 亚型
- IgG
- Top Product
- Discover our top product GCN1L1 Primary Antibody
-
anti-GCN1 General Control of Amino-Acid Synthesis 1-Like 1 (Yeast) (GCN1L1) antibody
GCN1L1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
-
- 应用备注
- WB,1:500 - 1:2000
- 说明
-
HIGH QUALITY
- 限制
- 仅限研究用
-
- 状态
- Liquid
- 缓冲液
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
-
- 抗原
- GCN1L1 (GCN1 General Control of Amino-Acid Synthesis 1-Like 1 (Yeast) (GCN1L1))
- 别名
- GCN1L1 (GCN1L1 产品)
- 别名
- GCN1 antibody, GCN1L antibody, PRIC295 antibody, 4932409G22 antibody, AL022764 antibody, G431004K08Rik antibody, mKIAA0219 antibody, GCN1, eIF2 alpha kinase activator homolog antibody, GCN1 general control of amino-acid synthesis 1-like 1 (yeast) antibody, GCN1 eIF2 alpha kinase activator-like 1 antibody, GCN1 antibody, Gcn1l1 antibody
- 背景
- Acts as a positive activator of the EIF2AK4/GCN2 protein kinase activity in response to amino acid starvation. Forms a complex with EIF2AK4/GCN2 on translating ribosomes, during this process, GCN1 seems to act as a chaperone to facilitate delivery of uncharged tRNAs that enter the A site of ribosomes to the tRNA-binding domain of EIF2AK4/GCN2, and hence stimulating EIF2AK4/GCN2 kinase activity. Participates in the repression of global protein synthesis and in gene-specific mRNA translation activation, such as the transcriptional activator ATF4, by promoting the EIF2AK4/GCN2-mediated phosphorylation of eukaryotic translation initiation factor 2 (eIF-2-alpha/EIF2S1 on 'Ser-52', and hence allowing ATF4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion.,GCN1,GCN1L,GCN1L1,PRIC295,Epigenetics & Nuclear Signaling,GCN1L1
- 分子量
- 292 kDa
- 基因ID
- 10985
- UniProt
- Q92616
-
You are here:
