Calpain, a heterodimer consisting of a large and a small subunit, is a major intracellular protease, although its function has not been well established. This gene encodes a muscle-specific member of the calpain large subunit family that specifically binds to titin. Mutations in this gene are associated with limb-girdle muscular dystrophies type 2A. Alternate promoters and alternative splicing result in multiple transcript variants encoding different isoforms and some variants are ubiquitously expressed.,CAPN3,CANP3,CANPL3,LGMD2,LGMD2A,nCL-1,p94,calpain-3,Signal Transduction,Cell Biology & Developmental Biology,Ubiquitin,Neuroscience,Calcium Signaling,CAPN3