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- 抗原 See all ATM 抗体
- ATM (Ataxia Telangiectasia Mutated (ATM))
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抗原表位
- AA 1900-2000
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This ATM antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 序列
- CLDKKSQRTM LAVVDYMRRQ KRPSSGTIFN DAFWLDLNYL EVAKVAQSCA AHFTALLYAE IYADKKSMDD QEKRSLAFEE GSQSTTISSL SEKSKEETGI S
- 交叉反应
- 人
- 产品特性
- Polyclonal Antibodies
- 纯化方法
- Affinity purification
- 免疫原
- A synthetic peptide corresponding to a sequence within amino acids 1900-2000 of human ATM (NP_000042.3).
- 亚型
- IgG
- Top Product
- Discover our top product ATM Primary Antibody
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- 应用备注
- WB,1:500 - 1:1000
- 说明
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HIGH QUALITY
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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1,2:5,6-dianhydrogalactitol inhibits human glioma cell growth in vivo and in vitro by arresting the cell cycle at G2/M phase." in: Acta pharmacologica Sinica, Vol. 38, Issue 4, pp. 561-570, (2017) (PubMed).
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1,2:5,6-dianhydrogalactitol inhibits human glioma cell growth in vivo and in vitro by arresting the cell cycle at G2/M phase." in: Acta pharmacologica Sinica, Vol. 38, Issue 4, pp. 561-570, (2017) (PubMed).
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- 抗原
- ATM (Ataxia Telangiectasia Mutated (ATM))
- 别名
- ATM (ATM 产品)
- 背景
- The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates, thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder.,AT1,ATA,ATC,ATD,ATDC,ATE,TEL1,TELO1,ATM,Epigenetics & Nuclear Signaling,Chromatin Modifying Enzymes,Phosphorylation,DNA Damage & Repair,Cancer,Tumor suppressors,Signal Transduction,Kinase,Serine/threonine kinases,Cell Biology & Developmental Biology,Apoptosis,Mitochondrial Control of Apoptosis,Cell Cycle,G1/S Checkpoint,G2/M DNA Damage Checkpoint,Immunology & Inflammation,NF-kB Signaling Pathway,ATM
- 分子量
- 350 kDa
- 基因ID
- 472
- UniProt
- Q13315
- 途径
- p53 Pathway, Apoptosis, DNA Damage Repair, Inositol Metabolic Process, Positive Regulation of Response to DNA Damage Stimulus
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