SMAD2 / SMAD3 (pSer423), (pSer425) 抗体
适用: 人
WB, IHC, IF
宿主: 兔
Polyclonal
unconjugated
(1 reference)-
- 抗原
- SMAD2 / SMAD3
-
抗原表位
- pSer423, pSer425
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适用
- 人
-
宿主
- 兔
-
克隆类型
- 多克隆
-
标记
- 非结合性
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
- 序列
- SSMS
- 交叉反应
- 人, 小鼠, 大鼠
- 产品特性
- Phosphorylated Antibodies
- 免疫原
- A synthetic phosphorylated peptide around S465 & S467 of human Smad2 (NP_005892.1).
- 亚型
- IgG
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anti-SMAD2 / SMAD3 (pSer423), (pSer425) antibody
适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-SMAD2 / SMAD3 (pThr8) antibody适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200
- 限制
- 仅限研究用
-
- 状态
- Liquid
- 缓冲液
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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: "Isoviolanthin Extracted from Dendrobium officinale Reverses TGF-β1-Mediated Epithelial⁻Mesenchymal Transition in Hepatocellular Carcinoma Cells via Deactivating the TGF-β/Smad and PI3K/Akt/mTOR ..." in: International journal of molecular sciences, Vol. 19, Issue 6, (2018) (PubMed).
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: "Isoviolanthin Extracted from Dendrobium officinale Reverses TGF-β1-Mediated Epithelial⁻Mesenchymal Transition in Hepatocellular Carcinoma Cells via Deactivating the TGF-β/Smad and PI3K/Akt/mTOR ..." in: International journal of molecular sciences, Vol. 19, Issue 6, (2018) (PubMed).
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- 抗原
- SMAD2 / SMAD3
- 别名
- SMAD2/SMAD3
- 背景
- The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012],HSPC193;HsT17436;JV15-2;LDS1C;LDS3;MADH3,Protein phosphorylation,Protein phosphorylation,Protein phosphorylation,SMAD2/SMAD3
- 分子量
- 48 kDa/52 kDa/25 kDa/35 kDa/43 kDa
- 基因ID
- 4087, 4088
- UniProt
- Q15796, P84022
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