MAP4K6 抗体
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- 抗原 See all MAP4K6 (MINK1) 抗体
- MAP4K6 (MINK1) (Misshapen-Like Kinase 1 (MINK1))
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适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This MAP4K6 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
- 免疫原
- misshapen-like kinase 1 (zebrafish)
- 亚型
- IgG
- Top Product
- Discover our top product MINK1 Primary Antibody
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 说明
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mouse brain tissue were subjected to SDS PAGE followed by western blot with FNab05191(MINK1 antibody) at dilution of 1:300
- 限制
- 仅限研究用
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- 缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freeze / thaw cycles.
- 储存条件
- -20 °C
- 有效期
- 12 months
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- 抗原
- MAP4K6 (MINK1) (Misshapen-Like Kinase 1 (MINK1))
- 别名
- MINK1 (MINK1 产品)
- 别名
- MINK1 antibody, MINK antibody, B55 antibody, MAP4K6 antibody, YSK2 antibody, ZC3 antibody, hMINK antibody, hMINKbeta antibody, MEKKK 6 antibody, Map4k6 antibody, RP23-122P1.6 antibody, Ysk2 antibody, misshapen like kinase 1 antibody, misshapen-like kinase 1 antibody, misshapen-like kinase 1 (zebrafish) antibody, MINK1 antibody, Mink1 antibody
- 背景
- Synonyms:B55, MAP4K6, Background:Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking. Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons. Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates: TANC1 upon stimulation by RAP2A, MBP and SMAD1. Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1. Isoform 4 can activate the JNK pathway. Involved in the regulation of actin cytoskeleton reorganization, cell-matrix adhesion, cell-cell adhesion and cell migration.
- 分子量
- 150 kDa
- 基因ID
- 50488
- UniProt
- Q8N4C8
- 途径
- Synaptic Membrane
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