ERK1 抗体
Quick Overview for ERK1 抗体 (ABIN5702776)
抗原
See all ERK1 (MAPK3) 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- ERK1/2 antibody
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免疫原
- mitogen-activated protein kinase 1
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亚型
- IgG
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应用备注
- WB : 1:1000-1:10000 IHC : 1:50-1:200 IF : 1:10-1:100
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说明
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HeLa cells were subjected to SDS PAGE followed by western blot with FNab02845(ERK1/2 antibody) at dilution of 1:1000
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限制
- 仅限研究用
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- ERK1 (MAPK3) (Mitogen-Activated Protein Kinase 3 (MAPK3))
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别名
- ERK1
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背景
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Synonyms: Mitogen-activated protein kinase 1 (MAP kinase 1, MAPK 1)|ERT1|Extracellular signal-regulated kinase 2 (ERK-2)|MAP kinase isoform p42 (p42-MAPK)|Mitogen-activated protein kinase 2 (MAP kinase 2, MAPK 2)|MAPK1|ERK2|PRKM1|PRKM2
Background: This gene encodes a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. One study also suggests that this protein acts as a transcriptional repressor independent of its kinase activity. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene.
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分子量
- 38-44 kDa
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UniProt
- P28482
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途径
- MAPK Pathway, RTK signaling, Interferon-gamma Pathway, Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway, Response to Growth Hormone Stimulus, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Hepatitis C, Protein targeting to Nucleus, Toll-Like Receptors Cascades, Signaling Events mediated by VEGFR1 and VEGFR2, Signaling of Hepatocyte Growth Factor Receptor, VEGFR1 Specific Signals, S100 Proteins
抗原
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