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SLAMF7 抗体

SLAMF7 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN5701905
发货至: 中国
  • 抗原 See all SLAMF7 抗体
    SLAMF7 (SLAM Family Member 7 (SLAMF7))
    适用
    • 39
    • 23
    • 3
    宿主
    • 31
    • 9
    • 3
    克隆类型
    • 34
    • 9
    多克隆
    标记
    • 23
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This SLAMF7 antibody is un-conjugated
    应用范围
    • 36
    • 18
    • 16
    • 9
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA
    免疫原
    SLAM family member 7
    亚型
    IgG
    Top Product
    Discover our top product SLAMF7 Primary Antibody
  • 应用备注
    Optimal working dilution should be determined by the investigator.
    限制
    仅限研究用
  • 缓冲液
    PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freeze / thaw cycles.
    储存条件
    -20 °C
    有效期
    12 months
  • 抗原
    SLAMF7 (SLAM Family Member 7 (SLAMF7))
    别名
    SLAMF7 (SLAMF7 产品)
    别名
    RGD1560190 antibody, SLAMF7 antibody, slaf7 antibody, 19A antibody, CD319 antibody, CRACC antibody, CS1 antibody, 19A24 antibody, 4930560D03Rik antibody, SLAM family member 7 antibody, Slamf7 antibody, SLAMF7 antibody, slaf7 antibody
    背景
    Synonyms:CS1 Background:Self-ligand receptor of the signaling lymphocytic activation molecule(SLAM) family. SLAM receptors triggered by homo-or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Isoform 1 mediates NK cell activation through a SH2D1A-independent extracellular signal-regulated ERK-mediated pathway(PubMed:11698418). Positively regulates NK cell functions by a mechanism dependent on phosphorylated SH2D1B. Downstream signaling implicates PLCG1, PLCG2 and PI3K(PubMed:16339536). In addition to heterotypic NK cells-target cells interactions also homotypic interactions between NK cells may contribute to activation. However, in the absence of SH2D1B, inhibits NK cell function. Acts also inhibitory in T-cells(By similarity). May play a role in lymphocyte adhesion(PubMed:11802771). In LPS-activated monocytes negatively regulates production of proinflammatory cytokines(PubMed:23695528). Isoform 3 does not mediate any NK cell activation.
    基因ID
    57823
    UniProt
    Q9NQ25
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