VPS4B 抗体
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- 抗原 See all VPS4B (vps4b) 抗体
- VPS4B (vps4b) (Vacuolar Protein Sorting 4 Homolog B (vps4b))
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适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This VPS4B antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunoprecipitation (IP), Immunofluorescence (IF)
- 免疫原
- vacuolar protein sorting 4 homolog B (S. cerevisiae)
- 亚型
- IgG
- Top Product
- Discover our top product vps4b Primary Antibody
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- 应用备注
- WB :1:500-1:5000,IP:1:500-1:5000,IF:1:10-1:100
- 说明
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Y79 cells were subjected to SDS PAGE followed by western blot with FNab09446(VPS4B antibody) at dilution of 1:500
- 限制
- 仅限研究用
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- 缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freeze / thaw cycles.
- 储存条件
- -20 °C
- 有效期
- 12 months
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- 抗原
- VPS4B (vps4b) (Vacuolar Protein Sorting 4 Homolog B (vps4b))
- 别名
- VPS4B (vps4b 产品)
- 别名
- zgc:63682 antibody, vps4a antibody, SKD1 antibody, SKD1B antibody, VPS4-2 antibody, 8030489C12Rik antibody, Skd1 antibody, vacuolar protein sorting 4 homolog B antibody, vacuolar protein sorting 4 homolog B S homeolog antibody, vacuolar protein sorting 4b homolog B (S. cerevisiae) antibody, vacuolar protein sorting 4 homolog B (S. cerevisiae) antibody, vacuolar protein sorting 4B antibody, Vps4b antibody, vps4b.S antibody, vps4b antibody, VPS4B antibody
- 背景
- Synonyms:MIG1, Protein SKD1, SKD1, VPS4 2, VPS42, VPS4B Background:Involved in late steps of the endosomal multivesicular bodies(MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane fission. Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles(ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. In conjunction with the ESCRT machinery also appears to function in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding(HIV-1 and other lentiviruses). VPS4A/B are required for the exosomal release of SDCBP, CD63 and syndecan(PubMed:22660413).
- 分子量
- 49kDa
- 基因ID
- 9525
- UniProt
- O75351
- 途径
- Microtubule Dynamics, CXCR4-mediated Signaling Events
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